| 胰岛素样生长因子-I与2型糖尿病患者骨密度关系的研究 |
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| 引用本文： | 孙明谨,李雪锋,陈世清,胡清,王芳,曾玉琴. 胰岛素样生长因子-I与2型糖尿病患者骨密度关系的研究[J]. 中国误诊学杂志, 2007, 7(23): 5456-5458 |
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| 作者姓名： | 孙明谨 李雪锋 陈世清 胡清 王芳 曾玉琴 |
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| 作者单位： | 郧阳医学院附属太和医院内分泌科,湖北,十堰,442000 |
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| 摘 要： | 目的:探讨胰岛素样生长因子-I(IGF-I)在2型糖尿病患者骨质疏松(OP)发病中的作用与机制。方法:用双能x线骨密度仪分别测定2型糖尿病患者骨密度值(BMD);用酶联免疫的方法测定受试者血清IGF-I的水平,并与正常对照组比较。结果:2型糖尿病组骨密度低于对照组(P<0.01);血清IGF-I水平低于对照组(P<0.01);糖尿病患者骨密度值与血清IGF-I水平显著正相关(P<0.01)。结论:2型糖尿病组OP发病率增高,与IGF-I水平降低导致骨形成减少有关。
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| 关 键 词： | 糖尿病 2型/血液 胰岛素样生长因子/代谢 骨密度/生理学 骨质疏松/病理生理学 人类 |
| 文章编号： | 1009-6647（2007）23-5456-03 |
| 修稿时间： | 2007-06-20 |
Relationship between Bone Mineral Density and Serum Insulin-Like Growth Factor-1 in Patients with Type 2 Diabetes Mellitus |
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| SUN Ming-jin;LI Xue-feng;CHEN Shi-qing;et al.. Relationship between Bone Mineral Density and Serum Insulin-Like Growth Factor-1 in Patients with Type 2 Diabetes Mellitus[J]. Chinese Journal of Misdiagnostics, 2007, 7(23): 5456-5458 |
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| Authors: | SUN Ming-jin LI Xue-feng CHEN Shi-qing et al. |
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| Affiliation: | Department of Endocrinology;Taihe Hospital of Yunyang Medical College;Shiyan 442000;China |
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| Abstract: | Objective:To explore the role of insulin-like growth factor-I(IGF-I) in onset of osteoporosis in patients with type 2 diabetes mellitus.Methods:BMD was measured by double-X ray bone mineral density meter.The level of serum IGF-I was detected by enzyme linked immunosorbant assay.Results:Compared with normal control group,the bone mineral density in type 2 diabetes was significantly lower(P<0.01),and the level of serum IGF-I was significantly lower(P<0.01).In type 2 diabetes mellitus group,the BMD was positively related with IGF-I (P<0.01).Conclusions:The morbidity of osteoporosis in type 2 diabetes mellitus is higher.IGF-I plays a critical role in the pathogenesis of bone formation. |
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| Keywords: | Diabetes Mellitus Type 2/blood Insulin-Like Growth Factor I/metabolism osteoporosis/physiopathology Bone Density/physiology Humans |
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