Psychotropic effects of corticotropin-releasing hormone stimulation in depressive patients |
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| Authors: | G Laux K P Lesch M Schwab |
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| Affiliation: | Department of Psychiatry, University of Würzburg, FRG. |
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| Abstract: | Synthetic human corticotropin-releasing hormone (hCRH) was administered as an intravenous bolus (100 micrograms) to 13 patients suffering from endogenous depression and to 12 healthy volunteers. Compared with controls, depressed patients showed a significant amelioration of mood and well-being 2 h after hCRH administration in the rating scales applied ('Befindlichkeits-Skala', 'Eigenschaftsw?rterliste', 'Kurzskala Stimmung-Aktivierung', Self-Rating Depression Scale, Hamilton Rating Scale for Depression). Based on our preliminary data, a psychotropic effect and at least a mediating function of hCRH regarding pathophysiology and etiopathogenesis of endogenous depressions must be assumed. |
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