| 基因芯片检测广东省汉族人群HLA-DQB1基因多态性 |
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| 引用本文： | 武大林,王晖,张文.基因芯片检测广东省汉族人群HLA-DQB1基因多态性[J].第三军医大学学报,2005,27(22):2230-2231. |
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| 作者姓名： | 武大林 王晖 张文 |
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| 作者单位： | 南方医科大学南方医院医学中心实验科,广州,510515;深圳益生堂生物企业有限公司,深圳,518026 |
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| 摘 要： | 目的调查研究了700名广东省汉族人群HLA-DQB1等位基因频率及多态性分布.方法采用深圳益生堂生物企业有限公司研制开发的"HLA-DQB1低分辨率基因分型芯片试剂盒",应用PCR-SSP SSO芯片检测技术,对700名广东省的中国人群进行基因分型.结果鉴定了10个HLA-DQB1等位基因.广东省人群HLA-DQB1等位基因频率分布为HLA-DQB1*05＞*0301＞*0303＞*0601＞*02＞*0302＞*04＞*0602＞*0604＞*0603.结论为我国疾病相关性研究、人类学研究提供了可靠的遗传学参数.
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| 关 键 词： | 基因芯片 HLA-DQB1 基因多态性 中国广东汉族人群 |
| 文章编号： | 1000-5404(2005)22-2230-02 |
| 收稿时间： | 2005-05-23 |
| 修稿时间： | 2005-09-12 |
HLA-DQB1 gene polymorphisms in Guangdong province detected by genechip |
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| WU Da-lin,WANG Hui,ZHANG Wen.HLA-DQB1 gene polymorphisms in Guangdong province detected by genechip[J].Acta Academiae Medicinae Militaris Tertiae,2005,27(22):2230-2231. |
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| Authors: | WU Da-lin WANG Hui ZHANG Wen |
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| Institution: | 1 Central Laboratory, Nanfang Hospital, South Medical University, Guangzhou 510515; Shenzhen Yi-Shengtang Biological LTD. , Shenzhen 518054, China |
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| Abstract: | Objective To explore HLA-DQB1 gene frequency(GF) in Southern China inhabitants.Methods DNA Microarray Kit for HLA-DQB1 LowRes Genotyping were used to detect HLA-DQB1 gene polymorphisms of 700 inhabitants in Southern China.Results Ten alleles of HLA-DQB1 were inspected and a series of gene frequency(GF) distribution was obtained as following: HLA-DQB1*05>*0301>*0303>*0601>*02>*0302>*04>*0602>*0604>*0603.Conclusion The GF data of Chinese in Southern China are useful to correlation of diseases and anthropologic research. |
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| Keywords: | HLA-DQB1 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
