Determination of 3,4-dimethylhippuric acid as a biological monitoring index for trimethylbenzene exposure in transfer printing workers |
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Authors: | Yukio Fukaya Isao Saito Tadao Matsumoto Yasuhiro Takeuchi Shinkan Tokudome |
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Affiliation: | (1) Department of Public Health, Nagoya City University Medical School, Kawasumi, Mizuho-cho, 467 Mizuho-ku, Nagoya, Japan;(2) Aichi Prefectural Institute of Public Health, Tsuji-machi, 462 Kita-ku, Nagoya, Japan;(3) Department of Hygiene, Nagoya University School of Medicine, 65 Tsurumai-cho, 466 Showa-ku, Nagoya, Japan |
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Abstract: | Summary The relationship between exposure to 1,2,4-trimethylbenzene (1,2,4-TMB) and urinary concentration of 3,4-dimethylhippuric acid (3,4-DMHA), one of its metabolites, was studied in workers involved in transfer printing. Airborne TMBs were sampled by an organic vapor monitoring badge and analyzed by capillary gas chromatography. Urinary 3,4-DMHA and creatinine were analyzed under the same conditions of high-performance liquid chromatography. The exposure concentration of 1,2,4-TMB among workers was around 25 ppm, the threshold limit value (TLV). The urinary concentration of 3,4-DMHA was low at the start of each shift and high at the end. Exposure to the TLV (25 ppm) of 1,2,4-TMB results in a urinary 3,4-DMHA concentration of 410 mg/g creatinine (r = 0.897, P < 0.001). Urinary 3,4-DMHA concentration could be used as a biological monitoring index for 1,2,4-TMB exposure. |
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Keywords: | Trimethylbenzene Dimethylhippuric acid Biological monitoring Urinary metabolite |
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