Diurnal variation of soluble CD40 ligand in patients with acute coronary syndrome. Soluble CD40 ligand and diurnal variation |
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Authors: | Dominguez-Rodriguez Alberto Abreu-Gonzalez Pedro Garcia-Gonzalez Martín J Kaski Juan Carlos |
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Institution: | a Department of Cardiology (Coronary Care Unit), University Hospital of Canarias, Tenerife, Spain b Department of Physiology, University of La Laguna, School of Medicine, Tenerife, Spain c Department of Cardiological Sciences, St. George's Hospital Medical School, London, United Kingdom |
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Abstract: | IntroductionWe sought to investigate whether day-night variations occur in the concentration of circulating soluble CD40 ligand in patients with acute coronary syndrome, as this may have practical implications.Materials and MethodsWe assessed 70 consecutive ST-segment elevation myocardial infarction patients admitted into the Coronary Care Unit and 50 control subjects. Each subject was studied under strictly controlled light/dark conditions. Blood samples were drawn at 09:00 h (light phase) and 02:00 h (dark phase). Nocturnal blood samples were drawn by a trained nurse, with the help of a minute torch with a dim red light in order to avoid any direct lighting on the patient during sleep. The soluble CD40 ligand was measured using a commercially available ELISA.ResultsSoluble CD40 ligand levels showed no diurnal variations in control subjects. In the ST-segment elevation myocardial infarction group, however, soluble CD40 ligand concentration (pg/mL) in the light phase was significantly higher than that in the dark phase (167.3 ± 63.2 vs 118.9 ± 48.3 pg/mL, p < 0.001).ConclusionsThe study shows for the first time the existence of diurnal variations in soluble CD40 ligand levels in ST-segment elevation myocardial infarction patients, which indicates the need for standardizing the time of blood sampling for the assessment of this molecule, at least in studies involving ST-segment elevation myocardial infarction patients. |
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Keywords: | sCD40L Soluble CD40 ligand CD40L CD40 ligand STEMI ST-segment elevation myocardial infarction CCU Coronary Care Unit |
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