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GABAB receptors within the ventral tegmental area are involved in the expression and acquisition of morphine-induced place preference in morphine-sensitized rats |
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| Authors: | Sahraei Hedayat Etemadi Leila Rostami Parvin Pourmotabbed Ali Zarrindast Mohammad-Reza Shams Jamal Ghoshooni Hassan Noroozzadeh Ali Esfandiari Behnaz Salimi Seyed Hossein |
| Institution: | a Department of Physiology and Biophysics and Applied Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran b Department of Biology, School of Science, North Branch of Tehran, Azad University, Iran c Department of Biology, Tarbiat Moalem University, Tehran, Iran d Department of Physiology, Kermanshah University of Medical Sciences, Kermanshah, Iran e Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Iran f Neuroscience Research Center, Shaheed Beheshti University of Medical Sciences, Iran g Department of Physiology and Biophysics and Behavioral Sciences Research Center, Baqiyatallah University of Medical Sciences, Iran h Department of Physiology and Biophysics and Military Health Research Center, Baqiyatallah University of Medical Sciences, Iran i Department of Psychology and Research Center of Exercise Physiology, Baqiyatallah University of Medical Sciences, Iran |
| Abstract: | The influence of intra-ventral tegmental area administration of gamma-amino-butyric-acid-B (GABAB) receptor agonist and antagonist on the expression and acquisition of morphine-induced conditioned place preference (CPP) in morphine-sensitized female rats was examined. Our pilot experiment showed that subcutaneous administration of morphine-(2.5, 5 and 7.5 mg/kg) induced CPP. Administration of one dose daily morphine (5 mg/kg) for 3 days followed by 5 days rest, enhanced the conditioning induced by ineffective doses of morphine (0.25, 0.5 and 1 mg/kg). Injections of GABAB receptor agonist, baclofen, (1.5 and 12 µg/rat) reduced the expression of morphine CPP whereas the dose of 6 µg/rat of the drug increased it. Baclofen also significantly reduced the acquisition of morphine CPP in morphine-sensitized animals. Administration of GABAB receptor antagonist, CGP 35348, significantly reduced the expression (12 µg/rat) and acquisition (1.5, 6 and 12 µg/rat) of morphine CPP in morphine-sensitized animals.In conclusion, results confirmed the importance of GABAB receptors within the ventral tegmental area of morphine CPP in morphine-sensitized female rats. |
| Keywords: | Morphine GABAB receptor subtypes Conditioned place preference Rat Sensitization |
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