静脉注射胺碘酮转复急性心肌梗死并发快速心房颤动的临床研究

目的:观察静脉应用胺碘酮对急性心肌梗死(acute myocardial infarction,AMI)并发快速心房颤动(atrialfibrillation,AF)患者的临床价值。方法:24例AMI快速房颤患者,先给静脉推注负荷量胺碘酮150 mg,继之持续静脉泵入,观察房颤转复、心室率控制情况、血压改变及不良反应。结果:24例患者用药后30 min6、h、24 h心室率分别为(120±12)次/min(、85±9)次/min(、75±10)次/min,较用药前(130±13)次/min显著降低。血压无明显变化。其中18例患者在24 h内转复为窦性心律,转复率为75%。1例出现窦缓,1例出现窦性停搏。结论:静脉应用胺碘酮治疗AMI并发快速房颤是一种安全有效的临床措施。

The chinical value of intravenous amiodarone for fast atrial fibrillation in patients with acute myocardial infarction

Objective: To determine the value of amiodarone in patients of acute myocardial infarction with fast atrial fibrillation.Methods: 150 mg amiodarone was intravenously load in 24 acute myocardial infarction patients with new fast atrial fibrillation, then continuously pumped amiodarone.The efficacy of amiodarone to reversion the atrial fibrillation,control the ventricular rate,change blood pressure and the side effecst of amiodarone were observed.Results: 18 patients were(about 75% patients) reversed to sinus rhythm.The ventricular rate at 30 minute、6 hour、24 hour was respectively(110±12)beats/min、(85±9)beats/min、(75±10)beats/min,which were significantly lower than the heart rate of(130±13)beats/min when the amiodarone was administered.Blood pressure did not change.Sinus bradycardia was observed in one patient and sinus arrest was observed in one patients.Conclusion: Intravenous amiodarone is a safe and effective clinic measure to fast atrial fibrillation patients with acute myocardial infarction.