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中药序贯治疗高龄老年非ST段抬高急性冠脉综合征的临床研究
引用本文:肖明生,程亚慧. 中药序贯治疗高龄老年非ST段抬高急性冠脉综合征的临床研究[J]. 中西医结合心脑血管病杂志, 2012, 10(8): 921-923
作者姓名:肖明生  程亚慧
作者单位:1. 中国人民解放军第九四医院 ,330002
2. 江西中医学院临床医学院2007级学生,330001
摘    要:目的 研究中药序贯治疗对高龄老年非ST段抬高急性冠脉综合征(NSTEIACS)的改善作用及安全性.方法 将入选高龄老年NSTEIACS 患者57例随机分为两组,治疗组29例,对照组28例.对照组予常规西医治疗,治疗组在对照组治疗基础上,采用中药序贯治疗,先予活血祛瘀之丹红注射液,而后改用益气滋阴之参麦注射液,分别使用15 d,共30 d.检测血栓相关指标、纤维蛋白原(Fg),对心电图ST段变化及心绞痛疗效指标进行评价;并跟踪随访3个月,观察两组心血管事件.结果 治疗组血栓相关指标及Fg下降程度明显优于对照组(P<0.05),心电图NST及ΣST改善及心绞痛疗效优于对照组(P<0.05),随访期间治疗组反复心绞痛(AP)发作、心力衰竭(HF)、心律失常及非致死性心肌梗死(MI)发生率较对照组减低(P<0.05).结论 中药序贯治疗能促进老年NSTEIACS患者的心肌再灌注,有效缓解心绞痛症状,减少心脏事件发生,安全性好,无严重不良反应.

关 键 词:中药序贯治疗  非ST段抬高急性冠脉综合征  老年人

Chinese Herbal Medicine Sequential Therapy for Elderly Non-ST-segment Elevation Acute Coronary Syndrome
Xiao Mingsheng , Cheng Yahui. Chinese Herbal Medicine Sequential Therapy for Elderly Non-ST-segment Elevation Acute Coronary Syndrome[J]. Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease, 2012, 10(8): 921-923
Authors:Xiao Mingsheng    Cheng Yahui
Affiliation:94 th Hospital of PLA(Nanchang 330002)
Abstract:Objective To study the effect and safety of Chinese herbal medicine sequential therapy on the elderly non-ST-segment elevation acute coronary syndrome(NSTE-ACS).Methods Fifty-seven elderly patients(pts) with NSTE-ACS were randomly divided into treatment group(n=29) treated with Danhong injection and Shenmai injection,and control group(n=28) treated with conventional western medicine treatment.Emboli index and fibrinogen(Fg)were tested.ECG ST-segment was evaluated.Angina pectoris indicators and the cardiovascular events were observed for 3 months.Results Thrombosis-related indicators and FG in treatment group were decreased significantly than that in control group(P<0 05).ECG NST,ΣST,and the improvement of angina in treatment group was better than that in control group(P<0.05).The angina attack,heart failure,cardiac arrhythmias,and non-fatal myocardial infarction were decreased in the treatment group during the follow-up 3 months(P<0.05).Conclusion Chinese herbal medicine sequential therapy can promote the myocardial reperfusion of elderly NSTE-ACS pts,effectively relieve angina symptoms,and reduce the incidence of cardiac events.
Keywords:Chinese herbal medicine sequential therapy  non-ST-segment elevation acute coronary syndrome  elderly
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