深圳地区劳务工幽门螺杆菌感染及消化性溃疡的相关性研究

目的 了解深圳地区劳务工幽门螺杆菌(Helicobacter pylori,HP)的感染情况及其与消化性溃疡(pepticulcer,PU)发病的关系,为PU的防治工作提供理论依据.方法 对首次接受胃镜检查的劳务工患者进行HP检测,接胃镜结果将患者分为PU组及非PU组,观察各组HP感染率,按HP检测结果将患者分为HP感染组及非感染组,观察各组PU的发病率.结果 共有6 250例患者接受了胃镜检查,PU组1 281例(20.5％),其中HP阳性1076例(84.0％)；非PU组4969例(79.5％),其中HP阳性1 837例(37.0％).两组比较差异有统计学意义(x2=32.21,P＜0.01),PU与HP感染高度相关(r=0.78).HP阳性2 913例,感染率为46.6％,其中PU 1 102例,占37.8％;HP阴性3 337例,其中PU 179例,占5.4％；两组比较差异有统计学意义(x2=122.36,P＜0.01),PU与HP感染相关(r=0.65).结论 深圳地区劳务工HP感染率为46.6％,PU患者检出率高,PU患者的HP感染率明显高于非PU患者,其发病与HP感染密切相关.

Correlation between Helicobacter pylori infection and peptic ulcer in Shenzhen labor workers

Abstract] Objective To investigate the correlation between Helicobacter pylori （HP） infection with peptic ulcer （PU） to provide a theoretical basis for its treatment and prevention. Methods Totally 6 250 patients with upper gastrointestinal symptoms in our hospital were examined by gastroscopy and ^13C-urea breath test. According to the gastroscopic results,the patients were divided into PU group and non-PU group. The HP infection rates were observed in each group. Simultaneously, these cases were divided into infected group and non-infected group according to whether infected with HP. The incidence of peptic ulcer was observed in each group. Results In 6 250 cases,there were 1 281 cases with PU（20.5%） ,among them, 1 076 cases were positive （84.0%） in HP detection. There were 4 969 cases without peptic ulcer （79.5%）, among them, 1 837 cases were positive （37.0%） in HP detection. The difference between two groups was statistically significant （X2=32.21, P〈0.01, r=0.78 ）. For totally cases,there were 2 913 cases with Helicobacter pylori infection （46.6%）,among them, 1 102 cases suffered from PU （37.8%）. 3 337 cases had no HP infection, among them, 179 cases suffered from PU （5.4%）. There was statistical difference in two groups（X2=122.36,P〈0.01 ,r=0.65）. Conclusion The HP infection rate is 46.6% in Shenzhen laber workers. The patients with PU have higher HP infection rate than those without peptic ulcer. The morbidity of PU is closely related with HP infection.