肠道微生物与儿童肥胖

肥胖是影响儿童和成人健康的一个严重的公共卫生问题,其病因复杂,是遗传、环境等多种因素共同作用的结果.越来越多的证据显示,肠道微生物参与了体重调控、能量代谢和炎症反应,在肥胖的发生中起了重要作用.自然分娩、母乳喂养和避免生命早期抗生素暴露有益于维持肠道微生物的平衡,可能降低未来发生肥胖的风险.益生元和益生菌可以改变肠道微生物构成,从而影响摄食和体重.探求肠道微生物与肥胖间的关系可为防治儿童肥胖打开新思路.

Gut microbiota and childhood obesity

Obesity is a serious public health issue affecting both children and adults. The causes that drive obesity appear to be complex,and a consensus hypothesis is that obesity is influenced by a mixture of envi-ronmental,genetic,and many other factors. Recent evidence suggests that gut microbiota is involved in the con-trol of body weight,energy homeostasis and inflammation,and gut microbiota,plays a role in the pathophysiolo-gy of obesity. Natural delivery,breastfeeding,and early antibiotic resistance are beneficial to maintaining the bal-ance of intestinal microbiota,which may reduce the risk of future obesity. Prebiotics and probiotics may alter the composition of gut microbiota and affect food intake and appetite and body weight. Exploring the relationship be-tween gut microbiota and obesity might provide new methods to prevent and treat children obesity.