中晚期宫颈鳞状细胞癌放化疗综合治疗的临床进展

宫颈癌是女性最常见的恶性肿瘤之一,在亚洲女性恶性肿瘤发病率中居第2位,仅次于乳腺癌,而死亡率位居第4位。目前,同步放化疗是中晚期宫颈癌的标准治疗方案,能提高治疗的有效率和患者的生存率,其不良反应患者可耐受,但同步放化疗的化疗方案,获益人群和靶向药物的联合应用仍有待于进一步研究。放疗可以在不同时段、与不同种类的化疗药物结合,提高治疗效果。相关研究表明,顺铂和奈达铂单药周疗方案与铂类联合氟尿嘧啶、替加氟等类药物联合化疗21天方案的疗效相当,但前者毒副作用较小。紫杉醇和奈达铂联合化疗是有效的巩固化疗方案。含顺铂的同步放化疗被推荐为局部晚期宫颈癌的首选治疗方案。

Clinical Progress of Combined Chemoradiotherapy for Advanced Cervical Squamous Cell Carcinoma

Cervical cancer is one of the most common malignancies in women, ranking the second in the incidence of malignancy in Asia, second only to breast cancer, and the mortality rate is at 4th place. At present, concurrent radiotherapy and chemotherapy is a standard treatment program for advanced cervical cancer, which can provide the effective rate of treatment and the survival rate of patients, adverse reactions can be tolerated, but the combined use of concurrent chemotherapy regimens, benefit groups and targeted drugs remains to be further studied. Radiotherapy can be combined at different times with different types of chemotherapeutic agents, to improve the therapeutic effect. Related studies have shown that cisplatin and nedaplatin monotherapy treatment has the quite effect compared with platinum combined with fluorouracil, tegafur and other drugs 21 days of the program, but the monotherapy treatment has the smaller toxic side effects. Paclitaxel and nedaplatin are effective in consolidating chemotherapy regimens. Cisplatin-containing concurrent radiochemotherapy is recommended as the preferred treatment of locally advanced cervical cancer.