髓系抑制细胞、Th17细胞在哮喘患儿外周血中的表达

目的 分析髓系抑制细胞(MDSCs)及Th17细胞在哮喘患儿外周血中的表达情况和临床意义.方法 选取自贡市第一人民医院儿科2013年6月至2015年8月收治的120例哮喘患儿作为观察组,另外选择87例健康儿童作为对照组.应用流式细胞术检测MDSCs、Th17细胞在哮喘患儿外周血中的表达情况.结果 和对照组相比,观察组MDSCs占有核细胞的百分比和Th17细胞占单个核细胞的百分比都显著升高(Hc值分别为56.14、45.98,均P<0.05),差异具有统计学意义.结论 从MDSCs、Th17细胞在哮喘患儿外周血中的表达情况来看,它们可能参与了婴幼儿哮喘的发生与发展过程.

Expressions of MDSCs and Th17 cells in peripheral blood of children with asthma

Objective To analyze the expressions and clinical significance of myeloid derived suppressor cells ( MDSCs) and Th17 cells in peripheral blood of children with asthma. Methods Totally 120 children with asthma in First People' s Hospital of Zigong from June 2013 to August 2015 were selected in observation group, and 87 healthy children were selected in control group. The expressions of MDSCs and Th17 cells in peripheral blood of children with asthma were detected by flow cytometry. Results Compared to the control group, in the observation group, the percentages of MDSCs cells in nuclear cells and Th17 cells in mononuclear cells were significantly increased ( Hc value was 56. 14 and 45. 98, respectively, both P<0. 05), and the differences were statistically significant. Conclusion Seeing from the expressions of MDSCs and Th17 cells in peripheral blood of children with asthma, we suspect that MDSCs and Th17 cells may involve in the occurrence and development of child asthma.