HLA-DRB1基因多态性与陕西汉族妇女患中重度EM风险的相关性 Association of HLA-DRB1 gene polymorphism with moderate to severe endometriosis in females of Han nationality in Shaanxi Province期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

HLA-DRB1基因多态性与陕西汉族妇女患中重度EM风险的相关性

引用本文：	黄晓春,吕茉琦,杜良智,任文娟,周党侠. HLA-DRB1基因多态性与陕西汉族妇女患中重度EM风险的相关性[J]. 中国妇幼健康研究, 2017, 28(3). DOI: 10.3969/j.issn.1673-5293.2017.03.016

作者姓名：	黄晓春吕茉琦杜良智任文娟周党侠

作者单位：	1. 西安市第四医院妇产科,陕西西安,710004;2. 西安交通大学医学部病理系,陕西西安710061;西安交通大学医学部生殖医学中心,陕西西安710061

摘要：	目的探讨HLA-DRB1基因多态性在陕西汉族中重度子宫内膜异位症(EM)人群中的分布及其与EM发病风险的关联性.方法采用聚合酶链反应-直接测序技术(PCR-SBT),检测50例中重度EM患者和52例正常对照人群中HLA-DRB1的基因多态性分型,分析其基因型分布及其与中重度EM发病风险的相关性.结果 HLA-DRB1基因在EM组和对照组人群中均呈高度多态性分布;EM组人群中检测到22种HLA-DRB1基因型,其中基因型频率大于5%分别为HLA-DRB107:01(18%),DRB115:01(12%),DRB109:01(11%),DRB112:01(7%),DRB112:02(7%),DRB114:54(6%),DRB115:02(6%)和DRB114:05(5%).在对照组中人群中检测到24种HLA-DRB1基因型,其中基因型频率大于5%分别为HLA-DRB115:01(16.3%),DRB107:01(14.4%),DRB112:02(8.7%),DRB112:01(8.7%),DRB109:01(6.7%)和DRB104:05(5.8%).HLA-DRB1各基因型在EM组与对照组中的分布未见明显统计学差异.结论 HLA-DRB1基因多态性与陕西汉族中重度EM发病风险无明显关联.
关键词：	HLA-DRB1基因子宫内膜异位症基因多态性聚合酶链反应-直接测序技术
Association of HLA-DRB1 gene polymorphism with moderate to severe endometriosis in females of Han nationality in Shaanxi Province

HUANG Xiao-chun,LYU Mo-qi,DU Liang-zhi,REN Wen-juan,ZHOU Dang-xia. Association of HLA-DRB1 gene polymorphism with moderate to severe endometriosis in females of Han nationality in Shaanxi Province[J]. Chinese Journal of Maternal and Child Health Research, 2017, 28(3). DOI: 10.3969/j.issn.1673-5293.2017.03.016

Authors:	HUANG Xiao-chun LYU Mo-qi DU Liang-zhi REN Wen-juan ZHOU Dang-xia

Abstract:	Objective To investigate the distribution of HLA-DRB1 gene polymorphism in females of Han nationality with moderate to severe endometriosis ( EM) in Shaanxi Province and its association with EM risk .Methods Polymerase chain reaction sequence-based typing ( PCR-SBT) method was used for DNA genotyping at HLA-DRB1 locus in 50 patients with moderate to severe EM and 52 healthy controls in females to analyze the association between genotype distribution of HLA -DRB1 alleles and risk of moderate to severe EM . Results Both in EM group and control group HLA-DRB1 appeared highly polymorphic .Twenty-two HLA-DRB1 alleles were detected in EM group, and the frequency of following genotypes was above 5%, HLA-DRB107:01 ( 18%) , DRB115:01 ( 12%) , DRB109:01 (11%), DRB112:01 (7%), DRB112:02 (7%), DRB114:54 (6%), DRB115:02 (6%) and DRB114:05 (5%). Twenty-four HLA-DRB1 alleles were detected in control group , and the frequency of following genotype was above 5%, HLA-DRB115:01 (16.3%), DRB107:01 (14.4%), DRB112:02 (8.7%), DRB112:01 (8.7%), DRB109:01 (6.7%) and DRB104:05 (5.8%).However, no significant differences in these allelic frequencies were found between EM group and control group .Conclusion HLA-DRB1 gene polymorphism does not significantly associated with risk of moderate to severe EM in females of Han nationality in Shaanxi Province.

Keywords:	HLA-DRB1 gene endometriosis ( EM) gene polymorphism polymerase chain reaction sequence-based typing ( PCR-SBT)
本文献已被万方数据等数据库收录！

设为首页 | 免责声明 | 关于勤云 | 加入收藏