细胞自噬在急性肾损伤中的作用

急性肾损伤(acute kidney injury,AKI)是一种临床预后较差的常见疾病,肾小管上皮细胞的损伤及死亡是其主要的病理特征.近年来,大量的研究已经表明在急性肾损伤过程中,自噬在肾小管上皮细胞中被诱导发生.在多种药理干预或自噬相关基因敲除的急性肾损伤模型中,自噬能通过抑制炎症反应、清除损伤的细胞器等相关机制减少细胞凋亡,保护肾脏损伤.但是也有研究表明自噬在急性肾损伤中起损害作用.阐明自噬在急性肾损伤中的作用及相关调节机制能够为急性肾损伤的治疗及预后提供重要线索.

Role of autophagy in acute kidney injury

Acute kidney injury(AKI)is a major kidney disease associated with poor clinical outcomes.The pathogenesis is characterized by tubular cell injury and death.Recent studies have demonstrated autophagy induction in proximal tubular cells during acute kidney injury.In the pharmacological or autophagy-related gene knockout AKI models,autophagy has been demonstrated to reduce the cell death and protect kidney through inhibiting the inflammatory response and removing the injury organelles.However,some studies suggest that autophagy has damage effects on the AKI.In conclusion,illuminating the roles and regulatory mechanism of autophagy in the AKI may provide the important theoretical clue for the therapy and prognosis of AKI.