前列腺癌miRNA生物标志物及其与辐射敏感性的研究进展

前列腺癌是男性泌尿系统最常见的恶性肿瘤之一。miRNA是近年来发现的一类长度为19~23 bp核苷酸的非编码小分子RNA，参与调节许多重要的细胞生物学行为，甚至在肿瘤的发生中发挥关键作用。前列腺癌基于血液miRNA生物标志物的研究不断涌现，但未发现特异性细胞外miRNA标志物。研究前列腺癌miRNA表达规律、作用机制，对深入探讨前列腺癌的发病机制、探索新的诊断和治疗途径意义重大。笔者主要综述针对健康人群、前列腺癌患者、转移性前列腺癌患者中不同miRNA丰度的不同，及前列腺癌miRNA对辐射敏感性的调节作用，试图探索miRNA作为前列腺癌生物标志物的线索。

Research progress in miRNA biomarkers of prostate cancer and radiosensitivity

Prostate cancer is the most common malignant tumor in the male urinary system.miRNA is a newly discovered small non-coding RNA of 19-23bp nucleotides,which was involved in regulating many important biological functions,even play a key role in tumor development.The blood research has indicated miRNA in blood could be a biomarker for diagnosis of prostate cancer but did not find specific extracellular miRNA as a prostate cancer biomarkers.Investigate the expression and the action mechanism of miRNA of prostate cancer have a great meaning to further discuss the pathogenesis of prostate cancer,search for new diagnostic and therapeutic method.This review focuses on the different abundance of miRNA among healthy population,patients with prostate cancer,patients with metastatic prostate cancer and moderating effect of miRNA of prostate cancer on tumor radiosensitivity,try to explore the clues of miRNA as biological markers for prostate cancer.