胃蛋白酶在咽喉反流疾病诊断中的应用

咽喉反流性疾病是近年来被临床医师逐渐认识并引起重视的一种疾病。美国耳鼻咽喉头颈外科学会将其定义为胃内H+和胃蛋白酶原经食管到达咽、喉、鼻、中耳、气管和支气管等部位所引起的临床症候群。随着逐渐深入的研究，学者对胃蛋白酶在咽喉反流病中的作用的认识逐渐提高，认为胃蛋白酶可以作为一种检测方法诊断咽喉反流病。

Effect of pepsin in the diagnosis of laryngopharyngeal reflux disease

Laryngopharyngeal reflux diseases (LPRD) refers to a kind of clinical syndrome that caused by the H+ and pepsin in the stomach entering the pharynx,larynx,nose,the middle ear,trachea and bronchi through esophagus,which has been gradually recognized and taken into account by otolaryngologist in recent years.Upper respiratory tract infections caused by LPRD are easily misdiagnosed or missed,due to its lack of specificity on clinical symptoms and signs,so correct diagnosis of LPRD is the key to giving patients proper treatment.With the deepening of LPRD research,otolaryngologists are gradually aware of its important role that pepsin plays in the cure of laryngopharynx trauma caused by reflux,so that the detection of upper and lower airway secretion of pepsin may be a possible sensitive diagnostic method for LPRD.