| 放射性肠损伤模型及其评价研究进展 |
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| 引用本文： | 王津晗,徐畅,王彦,刘强.放射性肠损伤模型及其评价研究进展[J].国际放射医学核医学杂志,2017,41(1):33-39,44. |
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| 作者姓名： | 王津晗 徐畅 王彦 刘强 |
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| 作者单位： | 300192, 北京协和医学院中国医学科学院放射医学研究所, 天津市放射医学与分子核医学重点实验室 |
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| 基金项目： | 国家自然科学基金(31670859)；中国医学科学院基本科研业务费项目(2016RC310017、2016ZX310068)Fund programs National Natural Science Foundation of China(31670859)； Fundamental Research Funds for CAMS＆PUMC |
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| 摘 要： | 辐射诱导的肠损伤是放疗造成的严重不良影响之一，可导致肠道局部缺血、纤维化、溃疡、肠狭窄和下消化道出血等。放疗引起的肠损伤的复杂性导致放射性肠损伤模型和研究评价指标也多种多样。笔者综述了近年来的放射性肠损伤模型及对放射性肠损伤的评价标准和研究方案，为今后的科学研究提供可靠的参考依据。
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| 关 键 词： | 肠 辐射损伤 模型 动物 评价研究 |
| 收稿时间： | 2016-11-29 |
Progress on the evaluating and establishing methods of radiation-induced intestinal injuries animal model |
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| Wang Jinhan,Xu Chang,Wang Yan,Liu Qiang.Progress on the evaluating and establishing methods of radiation-induced intestinal injuries animal model[J].International Journal of Radiation Medicine and Nuclear Medicine,2017,41(1):33-39,44. |
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| Authors: | Wang Jinhan Xu Chang Wang Yan Liu Qiang |
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| Institution: | Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science, Peking Union Medical College, Tianjin 300192, China |
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| Abstract: | Radiation-induced intestinal injuries, a devastating adverse effect of radiation therapy, can lead to local ischemia and fibrosis with the development of ulcers, strictures and lower gastrointestinal bleeding. As the complex causes of radiation-induced intestinal injuries, diverse evaluating methods and animal model had been established. In this context, the present review will focus on the evaluating and establishing methods of radiation-induced intestinal injuries animal model, what would provide ideas for related basic research. |
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| Keywords: | Intestines Radiation injuries Models animal Evaluation studies |
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