早产儿视网膜病发病机制的研究进展

早产儿视网膜病(retinopathy of prematurity,ROP)是一种与早产儿相关的眼部疾病,特点是在视网膜发育过程中血管异常的发生,重症者可引起视网膜脱离而失明,是儿童视力障碍和失明的主要原因.ROP是一个复杂的疾病,除了目前发现的吸氧、胎龄小、低出生体重、细胞因子等因素以外,促红细胞生成素、感染等因素均是可能影响本病发生的因素,根据其发病机制,早期发现、早期治疗已愈发重要,现就ROP发病机制的研究现状及进展进行综述.

Progress on the pathogenesis of retinopathy of prematurity

Retinopathy of prematurity(ROP)is a kind of eye disease associated with the premature infant.It is characterized by retinal vascular dysplasia,which can cause retinal detachment and blindness.It is the main reason of children with visual impairment and blindness.ROP is a complex disease,associated with oxygen therapy,low gestational age,low birth weight,cytokines and other factors.At present,erythropoietin and infection can also affect the occurrence of ROP.According to the pathogenesis,early detection and early treatment have become more important.This review summarizes the research progresses of pathogenesis in ROP.