脑白质损伤防治新标靶——神经血管单元

围生期脑白质损伤是导致早产儿神经系统发育受损甚至远期后遗症最常见的脑损伤形式.其发病机制复杂,目前尚缺乏有效的防治手段.近年来,神经血管单元作为神经系统结构和功能的整体,逐渐在神经科学领域引起关注.该文就脑白质中神经血管单元的组分及相互作用,脑白质损伤的病理生理、预防和治疗等方面的研究进展作一综述.

Novel intervention target for white matter injury-neurovascular unit

Perinatal cerebral white matter injury is the most common form of brain injury in premature infants which can lead to developmental disorders of the neurological system,even long-term neurological sequala.The pathogenesis of white matter injury is complicated,and until now there is no effective intervention option.In recent years,as the structural and functional integer of the nervous system,neurovascular unit has attracted much attention in the neuroscience field.The constituents of neurovascular unit and their interaction in the white matter,as well as the progress in the pathophysiology,prevention and treatment of white matter injury are reviewed in this paper.