比较超敏C反应蛋白和降钙素原在新生儿肺部感染中的诊断价值

目的 比较超敏C反应蛋白与降钙素原在新生儿肺部感染中的临床诊断价值.方法 自2014年1月至2015年12月,收集嘉兴市妇幼保健院出生的新生儿531例,根据是否合并肺部感染将新生儿分为肺部感染组和对照组,主要观察指标为超敏C反应蛋白和降钙素原,并分析超敏C反应蛋白和降钙素原在诊断新生儿感染中的临床价值.结果 肺部感染组新生儿超敏C反应蛋白、降钙素原、C反应蛋白、白细胞和中性粒细胞较对照组均明显增高,差异均有统计学意义(t值分别为12.459、18.486、9.437、8.389、10.485,均P<0.05).超敏C反应蛋白和降钙素原在诊断新生儿肺部感染中的曲线下面积分别为0.879(95%CI:0.825~0.920)和0.858(95%CI:0.792~0.925).Z检验示超敏C反应蛋白和降钙素原在诊断新生儿肺部感染中曲线下面积比较差异无统计学意义(P>0.05),但较C反应蛋白、白细胞和中性粒细胞高(P<0.05).结论 超敏C反应蛋白和降钙素原在诊断新生儿肺部感染中可能有较好的临床应用价值.

Comparison of clinical values of high-sensitivity C-reactive protein and calcitonin in diagnosis of neonatal pulmonary infection

Objective To compare the clinical values of high-sensitivity C-reactive protein and calcitonin in diagnosis of neonatal pulmonary infection. Methods From January 2014 to December 2015, 531 neonates were prospectively enrolled in this study in Maternal and Child Health-Care Hospital of Jiaxing. According to the infection of pulmonary, these neonates were assigned to infection group and control group to observe high-sensitivity C-reactive protein and calcitonin. The diagnostic values of high-sensitivity C-reactive protein and calcitonin in neonatal pulmonary infection were studied. Results Compared to neonates in the control group, cases in the infection group got significantly higher levels of high-sensitivity C-reactive protein, calcitonin, C-reactive protein, white blood cell and neutrophil ( t value was 12. 459, 18. 486, 9. 437, 8. 389 and 10. 485, respectively, all P<0. 05). The ROC area of high-sensitivity C-reactive protein and calcitonin in diagnosing neonatal pulmonary infection was 0. 879 (95%CI:0. 825-0. 920) and 0. 858 (95%CI:0. 792-0. 925), respectively. Z test showed that there was no statistical significance in the ROC area of high-sensitivity C-reactive protein and calcitonin in diagnosing neonatal pulmonary infection (P>0. 05), while both the ROC areas were higher than C-reactive protein, white blood cell and neutrophil (P<0. 05). Conclusion Both high-sensitivity C-reactive protein and calcitonin show better diagnostic values in neonatal pulmonary infection.