| 支持细胞在哺乳动物耳蜗发育及功能中的作用 |
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| 引用本文： | 陈佳瑞,杨军. 支持细胞在哺乳动物耳蜗发育及功能中的作用[J]. 国际耳鼻咽喉头颈外科杂志, 2017, 41(4): 187. DOI: 10.3760/cma.j.issn.1673-4106.2017.04.001 |
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| 作者姓名： | 陈佳瑞 杨军 |
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| 作者单位： | 1. 200092 上海交通大学医学院附属新华医院耳鼻咽喉头颈外科,上海市耳鼻疾病转化医学重点实验室,上海交通大学医学院耳科学研究所;200062 上海交通大学附属上海市儿童医院耳鼻咽喉头颈外科;2. 200092 上海交通大学医学院附属新华医院耳鼻咽喉头颈外科,上海市耳鼻疾病转化医学重点实验室,上海交通大学医学院耳科学研究所 |
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| 基金项目： | 上海交通大学医学院科技创新自然基金青年项目，国家自然科学基金，上海市科委优秀学科带头人计划(16XD1402200)Natural Science and Technology Innovation Fund of Shanghai Jiao Tong University School of Medicine，National Natural Science Foundation of China，Shanghai Municipal Science and Technology Committee of Shanghai Outstanding Academic Leaders Plan |
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| 摘 要： | 耳蜗的感觉上皮细胞有毛细胞和支持细胞两种类型.许多研究旨在探讨听力损失的基本机制,重点针对毛细胞和螺旋神经元,较少关注支持细胞.目前对支持细胞作用的了解已从单纯的结构支持扩展到耳蜗毛细胞分化发育、耳蜗离子稳态、毛细胞感音功能的调节以及突触发生发育、毛细胞损伤修复的多个方面.本文对支持细胞在哺乳动物耳蜗发育及功能中的关键作用做一综述.
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| 关 键 词： | 耳蜗 支持细胞 毛细胞 螺旋神经元 发育 |
Role of the supporting cells in the development and function of mammalian cochlea |
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| Chen Jiarui,Yang Jun. Role of the supporting cells in the development and function of mammalian cochlea[J]. International Journal of Otolaryngology-Head and Neck Surgery, 2017, 41(4): 187. DOI: 10.3760/cma.j.issn.1673-4106.2017.04.001 |
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| Authors: | Chen Jiarui Yang Jun |
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| Abstract: | The sensory epithelia of the cochlea contains two major cell types,namely hair cells and supporting cells.Many studies aiming to investigate the underlying mechanisms of hearing loss focus on the hair cells and spiral ganglion neurons of the inner ear,while fewer studies on the supporting cell.Current understanding of the role of supporting cells has expanded from structural support to the development of cochlear homeostasis,regulation of the function of hair cells,and the development of synapses and the repair of hair cell damage.Here we review recent studies that highlight the critical roles supporting cells play in the development and function of mammalian cochlea. |
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| Keywords: | Cochlea supporting cells,Hair Cells spiral ganglion neuron,development |
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