| P33ING1在口腔鳞状细胞癌中的表达及意义 |
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| 引用本文： | 董海英,陈英新,董帅,王晓峰,焦卫博. P33ING1在口腔鳞状细胞癌中的表达及意义[J]. 实用口腔医学杂志, 2007, 23(1): 43-45 |
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| 作者姓名： | 董海英 陈英新 董帅 王晓峰 焦卫博 |
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| 作者单位： | 1. 长春吉林大学口腔医学院口腔黏膜病科,130041
2. 天津市蓟县卫生防病站 |
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| 摘 要： | 目的:研究P33ING1蛋白表达与口腔鳞状细胞癌发生发展的关系。方法:应用免疫组化检测2004～2006年收治的30例口腔鳞状细胞癌组织中的P33ING1表达情况。结果:口腔鳞状细胞癌中P33ING1蛋白表达阳性率为40%(12/30),明显低于对照组的100%(15/15),两者比较差异有显著性(χ2=10.272,P<0.05)。结论:P33ING1蛋白在口腔鳞状细胞癌组织中的表达下降,提示P33ING1蛋白可能在口腔鳞癌的发生发展中有重要意义。
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| 关 键 词： | 鳞状细胞癌 口腔肿瘤 肿瘤蛋白质类 |
| 文章编号： | 1001-3733(2007)-01-0043-03 |
| 修稿时间： | 2006-03-24 |
P33ING1 expression in oral squamous cell carcinoma |
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| Dong Haiying , Chen Yingxin ,Dong Shuai ,et al.. P33ING1 expression in oral squamous cell carcinoma[J]. Journal of Practical Stomatology, 2007, 23(1): 43-45 |
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| Authors: | Dong Haiying Chen Yingxin Dong Shuai et al. |
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| Affiliation: | Department of Stomatology ,Stomatological Hospital of Jilin University, Changchun 130041, China |
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| Abstract: | Objective:To investigate the expression of P33~(ING1) protein in oral squamous cell carcinoma(OSCC) and its clinical significance. Methods:All samples of normal and cancer tissues from 30 patients with OSCC were examined for protein expression of P33~(ING1) by SP immunohistochemical staining.Results:The positive rate of P33ING1 in OSCC was 40%, that in normal oral mucosa tissue 100% (P<0.05).The P33~(ING1) positive rate in highly, moderately and lowly differentiated OSCC was 82.8%, 60.0% and 33.3% respectively.Conclusion:The low expression of P33~(ING1) may be an important factor related to carcinogenesis and development of OSCC. |
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| Keywords: | P33ING1 |
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