| 血清药理法研究补肾化瘀解毒方对肺癌耐药细胞内药物浓度的作用 |
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| 引用本文： | 曹勇,张丹,郑广娟,张静. 血清药理法研究补肾化瘀解毒方对肺癌耐药细胞内药物浓度的作用[J]. 中药材, 2003, 26(4): 263-265 |
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| 作者姓名： | 曹勇 张丹 郑广娟 张静 |
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| 作者单位： | 1. 暨南大学医学院,广州,510632
2. 山东中医药大学肿瘤药理室,济南,250014 |
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| 基金项目： | 中国博士后基金(中博基[2000]5号) |
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| 摘 要： | 为了探讨补肾化瘀解毒方对肺癌耐药细胞内Rh123浓度的作用,选择人肺腺癌A549/DDP耐药细胞株为模型,采用荷瘤动物血清药理及流式细胞法,并与正常动物药物血清为对照,结果补肾化瘀解毒方荷瘤动物药物血清能显著提高肺癌A549/DDP耐药细胞内Rh123浓度(P<0.05),与正常动物药物血清无显著性差异(P>0.05),表明补肾化瘀解毒方药物血清能提高肺癌耐药细胞内药物浓度作用。
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| 关 键 词： | 血清药理法 研究 肺癌 耐药细胞 补肾化瘀解毒方 流式细胞法 |
| 修稿时间： | 2002-12-18 |
Study on Effect of Drug Concentration of "Bushen huayu jiedu fang" Drug Serum on Drug-Resistance Lung Cancer Cells with Serum Pharmacology |
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| Cao Yong,Zhang Dan,Zheng Guangjuan,Zhang Jing. Study on Effect of Drug Concentration of "Bushen huayu jiedu fang" Drug Serum on Drug-Resistance Lung Cancer Cells with Serum Pharmacology[J]. Journal of Chinese medicinal materials, 2003, 26(4): 263-265 |
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| Authors: | Cao Yong Zhang Dan Zheng Guangjuan Zhang Jing |
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| Affiliation: | Medical School, Jinan University, Guangzhou 510632. |
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| Abstract: | To explore RH123 ion concentration effect of "Bushen huayu jiedu fang" (BSHYJD) on drug-resistance lung cancer cells, tumor-bearing animal drug-serum pharmacology and flow cytometry method were utilitied. In contrast with normal animal drug serum, BSHYJD drug-serum of tumor-bearing animal would markedly increase Rh123 concentration in drug-resistance lung cancer cells(P <0. 05) ,but which hasn' t marked discrepancy in contrast with normal animal drug-serum (P >0. 05) ,that indicated BSHYJD drug-serum has inceased drug concentration in drug-resistance lung cancer cells. |
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| Keywords: | Bushen huayu jiedu fang" ,Serum pharmocology,Flow cytometry |
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