外阴阴道假丝酵母菌病致病菌株调查及药敏分析

目的 探讨外阴阴道假丝酵母菌病(vulvovaginal candidiasis,VVC)致病菌株的分布和药敏.方法 采用法国CHROMagar显色培养基及梅里埃YBC酵母菌鉴定卡分离鉴定菌株,Rocso纸片扩散法进行药敏试验.结果 VVC致病菌株以白假丝酵母菌为主,占95.02%(191/201).致病菌株对酮康唑、制霉菌素、克霉唑、两性霉素B、氟康唑的敏感率较高,对咪康唑、益康唑、伊曲康唑的耐药率较高.结论 不同致病菌株对不同药物敏感性存在较大差异,临床上应重视假丝酵母菌的培养、鉴定和药敏试验,合理选用抗真菌药物.

Study on Pathogenic Candida Species and Antifungal Susceptibilities of Vulvovaginal Candidiasis

Objective To explore pathogenic candida species and antifungal susceptibilities of vulvovaginal candidiasis.Methods The CHROMagar candida color medium and YBC Card identification system were applied to isolate and identify candida strains.Drug sensitivity was analyzed by the Rocso disk diffusion method.Results Candida albicans was the most common species of pathogenic yeasts.Ketoconazole,nystain,clotrimazole,amphotericin B and fluconazol had good antifungal effects to yeasts,miconazole,econazole and itraconazole had less effects.Conclusion Medication should be accorded with the results of antifungal susceptibility test.