Effects of pallidotomy and bilateral
subthalamic stimulation on cognitive
function in Parkinson disease |
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Authors: | A?Gironell Email author" target="_blank">J?KulisevskyEmail author L?Rami N?Fortuny C?García-Sánchez B?Pascual-Sedano |
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Institution: | (1) Cognitive and Movement Disorders Section Dept. of Neurology, Sant Pau Hospital Autonomous University of Barcelona, Barcelona, Catalonia, Spain;(2) Servei de Neurologia, Hospital de la Santa Creu i Sant Pau Sant Antoni M.Claret, 170 08025 Barcelona, Spain |
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Abstract: | Unilateral pallidotomy
and bilateral subthalamic deep
brain stimulation (STN-DBS) for
Parkinson s disease (PD) have
demonstrated a positive effect
on motor functions. However,
further studies are needed of the
unintended cognitive effects
accompanying these new surgical
procedures. We studied the consequences
of unilateral pallidotomy
and STN-DBS on cognitive function
in a controlled comparative
design. Sixteen consecutive PD patients
were assessed before and 6
months after unilateral pallidotomy
(n = 8) and bilateral STN-DBS
(n = 8). The same assessments were
performed in a control group of
eight non-operated matched PD
patients recruited from surgery
candidates who refused operation.
The neuropsychological battery
consisted of test measuring memory,
attention, arithmetic, problem
solving and language, as well as
visuospatial, executive and premotor
functions. An analysis of variance
(factors time and treatment)
was applied. No statistically significant
differences were found in the
presurgical evaluation of clinical
and demographic data for the three
treatment groups. The controlled
comparison between presurgical
and postsurgical performance revealed
no significant changes in the
cognitive domains tested in the
pallidotomy group. The STN-DBS
group showed a selective significant
worsening of semantic verbal
fluency (p = 0.005). This controlled
comparative study suggests that
neither unilateral pallidotomy nor
bilateral STN-DBS have global adverse
cognitive consequences, but
bilateral STN-DBS may cause a selective
decrease in verbal fluency. |
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Keywords: | pallidotomy subthalamus deep brain
stimulation Parkinson s disease" target="_blank">gif" alt="rsquo" align="BASELINE" BORDER="0">s disease neuropsychology |
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