| 阴离子表面活性剂滴定法测定盐酸地芬尼多片的含量及含量均匀度 |
| |
| 引用本文： | 付萍萍,郭怀忠,郑清芬. 阴离子表面活性剂滴定法测定盐酸地芬尼多片的含量及含量均匀度[J]. 中国药事, 2002, 16(8): 487-488 |
| |
| 作者姓名： | 付萍萍 郭怀忠 郑清芬 |
| |
| 作者单位： | 1. 河北省保定市药品检验所,071051
2. 河北省儿童医院 |
| |
| 摘 要： | 本文采用阴离子表面活性剂滴定法测定盐酸地芬尼多片的含量及含量均匀度，选用磺基丁二酸钠二辛酯作滴定剂，氯仿为萃取剂，二甲基黄-溶剂蓝19混合液作指示剂，终点为由绿色变为红灰色。结果表明盐酸地芬尼多的称样量与滴定体积呈良好的线性关系，r=0.9997。平均回收率为100.60%(n=9)，RSD为0.74%，本法操作简便快速，结果准确可靠，可用于盐酸地芬尼多片的常规分析。
|
| 关 键 词： | 阴离子表面活性剂滴定法 盐酸地芬尼多片 含量均匀度 含量测定 磺基丁二酸钠二辛酯 |
| 文章编号： | 1002-7777(2002)08-0487-02 |
Determination of Diphenidol Hydrochloride Tablets and Its Content Uniformity by Anionic Surfactant Titration |
| |
| Fu Pingping Guo Huaizhong and Zheng Qingfen. Determination of Diphenidol Hydrochloride Tablets and Its Content Uniformity by Anionic Surfactant Titration[J]. Chinese Pharmaceutical Affairs, 2002, 16(8): 487-488 |
| |
| Authors: | Fu Pingping Guo Huaizhong and Zheng Qingfen |
| |
| Affiliation: | Fu Pingping Guo Huaizhong and Zheng Qingfen 1 |
| |
| Abstract: | An anionic surfactant titration was established for the determination of diphenidol hydrochloride tablet and content uniformity. Dioctyl sodium sulphosuccinate and chloroform were used as titrant and extractant, respectively, and dimethyl yellow-solvent coerule 19 as indicator. At the end-point, the color of the chloroform phase changed from green to red-grey. The method is simple, rapid and reliable, and can be used for quality control of diphenidol hydrochloride tablets. |
| |
| Keywords: | diphenidol hydrochloride dioctyl sodium sulphosuccinate titration |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
