呼吸道合胞病毒感染后婴幼儿喘息患者血清leptin水平的变化

目的 通过测量呼吸道合胞病毒肺炎儿童患者瘦素(leptin)的水平,探讨瘦素与呼吸道合胞病毒感染后婴幼儿喘息间的相互关系.方法 43例呼吸道合胞病毒感染后婴幼儿分别于入院后24h内、治疗结束及出院后12周用放射免疫法检测血清leptin水平,并随访2年.根据患儿喘息发作的情况,分为婴儿哮喘组和非哮喘组;另选10名健康儿童血清标本作对照.结果 BSV感染后喘息发作≥3次的婴幼儿患儿,占41.9%.治疗前,哮喘组和非哮喘组血清leptin水平均高于对照组,差异有统计学意义(t=3.41、2.64,P<0.05).治疗后,哮喘组血清leptin水平高于非哮喘组和对照组,差异有统计学意义(t=5.74、6.23,P<0.05).出院12周后复查,哮喘组血清leptin水平仍高于非哮喘组和对照组,差异有统计学意义(t=6.32、6.11,P<0.05);而非哮喘组血清leptin水平和对照组比较,差异无统计学意义(t=0.81,P>0.05).结论 呼吸道合胞病毒感染后喘息发作≥3次的婴幼儿血清leptin水平较健康同龄儿童及非哮喘儿童明显升高,持续高leptin水平可能是BSV感染后婴儿哮喘的高危因素之一.

The role of serum leptin in infants with wheezing after respiratory syncytial virus infected

Objective To determine the role of serum leptin in infants with wheezing after respiratory syncytial virus infected. Methods 43 infants infected with RSV were given blood samples to detect leptin concentration with radioimmunoassays (RIA) within 24 hours after admission into hospital, discharged and 12 weeks later. Then, they were followed up for 2 years. 10 healthy children of the same age served as controls. Results 41.9% infants developed asthma after infected with RSV. Compared to control group, the serum level of leptin in the asthma group and non-asthma group were significantly higher before treatment ( t = 3.41 and 2.64 respectively, P < 0.05). When they were discharged, the serum level of leptin in the asthma group was significantly higher than that in non-asthma group and control group ( t = 5.74 and 6.23, respectively, P < 0.05). 12 weeks later, the serum level of leptin in the asthma group was still significantly higher than that in non-asthma group and control group ( t = 6.32 and 6.11, respectively, P < 0.05), but there were no difference between non-asthma group and control group ( t = 0.81, P > 0.05 ). Conclusion The serum level of leptin in infants with asthma after RSV infected was higher than that in healthy and non-asthma children. Persistent higher level of leptin may play an important role in infants with asthma after RSV infected.