Lymphocyte subset reconstitution in pediatric liver recipients induced with steroid-free rabbit anti-human thymocyte globulin |
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Authors: | Talukdar Anjan AshokKumar Chethan Farrar Jennifer Wilson Patrick Janakiramanan Arun Tregaskes Mary Sindhi Rakesh |
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Affiliation: | Pediatric Transplantation Laboratory, Hillman Center for Pediatric Transplantation, Childrens Hospital of Pgh and the University of Pittsburgh, Pittsburgh, PA, USA. |
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Abstract: | Multiple measurements of lymphocyte subsets in 91 children treated with steroid-free tacrolimus, and rabbit anti-human thymocyte globulin induction demonstrate early reconstitution of T-cytotoxic cells, and gradual reconstitution of all other subsets, which is complete after one yr. Rejection-prone children demonstrate significantly higher counts of lymphocytes and all subsets prior to liver transplantation, and may exemplify one basis for enhanced baseline immunocompetence. |
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Keywords: | lymphocyte depleting antibodies pediatric liver transplantation immunosuppression lymphocyte subsets |
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