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Lymphocyte subset reconstitution in pediatric liver recipients induced with steroid-free rabbit anti-human thymocyte globulin
Authors:Talukdar Anjan  AshokKumar Chethan  Farrar Jennifer  Wilson Patrick  Janakiramanan Arun  Tregaskes Mary  Sindhi Rakesh
Affiliation:Pediatric Transplantation Laboratory, Hillman Center for Pediatric Transplantation, Childrens Hospital of Pgh and the University of Pittsburgh, Pittsburgh, PA, USA.
Abstract:Multiple measurements of lymphocyte subsets in 91 children treated with steroid-free tacrolimus, and rabbit anti-human thymocyte globulin induction demonstrate early reconstitution of T-cytotoxic cells, and gradual reconstitution of all other subsets, which is complete after one yr. Rejection-prone children demonstrate significantly higher counts of lymphocytes and all subsets prior to liver transplantation, and may exemplify one basis for enhanced baseline immunocompetence.
Keywords:lymphocyte depleting antibodies  pediatric  liver transplantation  immunosuppression  lymphocyte subsets
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