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| 应用边际回归模型研究原发性肝癌的家庭相关 | |
| 引用本文： | 郜艳晖,姜庆五,周学富,丁保国,王如鸿,陈思东. 应用边际回归模型研究原发性肝癌的家庭相关[J]. 中国医院统计, 2008, 15(2): 97-100 |
| 作者姓名： | 郜艳晖 姜庆五 周学富 丁保国 王如鸿 陈思东 |
| 作者单位： | 1. 广州市,广东药学院公共卫生学院卫生统计学教研室,510310 2. 复旦大学公共卫生学院流行病学教研室 3. 泰兴市疾病预防控制中心 |
| 摘 要： | 目的探讨泰兴市原发性肝癌的家庭聚集性。方法采用病例对照家系设计收集家系资料，应用边际回归模型方法分析亲属间肝癌的家庭相关大小和模式。结果肝癌病例的亲属比对照亲属有更高的疾病风险。调整了乙肝表面抗原后，亲属间的相关不再有统计学意义。结论边际回归模型可用于家系资料，研究表明肝癌存在家庭聚集性，HBV感染在肝癌的家庭聚集性中起着很重要的作用。 |
| 关 键 词： | 原发性肝癌 家系研究 家庭相关 |
A study on familial correlation of HCC using marginal regression model |
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| Affiliation: | GAO Yan-hui, JIANG Qing-wu, ZHOU Xue-fu, et al. (Department of Epidemiology and Health Statistics, College of Public Health, Guangdong College of Pharmacy, Guangzhou 510310, China) |
| Abstract: | Objective To explore the familial aggregation of HCC in Taixing. Methods We applied case-control family design to measure the familial correlation using marginal regression model. Results The relatives of case had higher disease risk than ones of the control. When HBsAg was adjusted, the association parameters among relatives were no longer statistically significant. Conclusion Marginal regression model could be used for family data. HCC had familial aggregation and HBV infection played an important role in familial aggregation of HCC. |
| Keywords: | HCC Family study Familial correlation |
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