氯诺昔康复合不同剂量舒芬太尼用于妇科手术患者术后自控镇痛的疗效观察

目的观察氯诺昔康复合不同剂量舒芬太尼用于妇科手术患者术后自控镇痛的临床效果。方法选择84例ASAⅠ～Ⅱ级的妇科择期手术患者，按照术后静脉镇痛的方案随机分为A、B、C3组，每组28例。A组为氯诺昔康40mg＋舒芬太尼50μg，B组为氯诺昔康40mg＋舒芬太尼75μg，C组为氯诺昔康40mg＋舒芬太尼100μg，各组均用生理盐水稀释至100ml。患者清醒拔管后，接电子镇痛泵，基础流量2ml／h，PCA剂量0．5ml／次，锁定时间15min。记录患者术后4、8、12、24、48h的VAS评分和不良反应。结果术后4、8、12hC组的VAS评分显著低于A组，差异有统计学意义（P〈0．05）。3组不良反应的发生率比较，差异无统计学意义（P〉0．05）。结论氯诺昔康40mg＋舒芬太尼100μg用于妇科手术后静脉自控镇痛效果良好，且不良反应少。

Application of lornoxicam combined with different dosage of sufentanil in patients-controlled intravenous analgesia after gynecologic operation

Objective To observe postoperative analgesia effect of patient-controlled intravenous analgesia（PCIA） with lornoxicam combined with different dosage of sufentanil after gynecilogical operation . Methods Eight-four ASA Ⅰ～Ⅱ patients undergoing gynecilogical operation were randomly assigned into group A, B and C. Group A was treated with lomoxieam 40mg＋ sufentanil 50μg ＋ NaCl to 10Oral, Group B with lomoxieam 40mg＋ sufentanil 75μg ＋ NaCl to 100ml, and Group C with lomoxieam 40mg＋ sufentanil 100p~g ＋NaCl to 100ml postoperatively. PCIA was administered with background infusion 2ml/h, bolus 2ml,lockout-time 15 minutes by electronic analgesia pump after extubation consciously. The visual analog scale （VAS）and incidence of side effects were recorded at 4 、8 、12、24、48h after operation. Results The VAS of the group C at 4 、 8、12h was significantly less than that of the group A（ P〈0. 05 ）. There were no significant difference of the incidences of adverse reactions among three groups. Conclusion PCIA with lornoxieam 40mg＋ sufentanil 100μg was safe and effective for patients after after gynecologic operation.