| 2-二乙胺基甲基咪唑的合成 |
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| 引用本文： | 王钝,全哲明,王硕冰,于飞. 2-二乙胺基甲基咪唑的合成[J]. 中国医药工业杂志, 2008, 39(10) |
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| 作者姓名： | 王钝 全哲明 王硕冰 于飞 |
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| 作者单位： | 1. 沈阳药科大学,辽宁沈阳,110016
2. 哈药集团三精制药有限公司,黑龙江哈尔滨,101700 |
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| 摘 要： | 咪唑和苯甲酰氯经酰化、成盐、催化氢化还原和水解反应制得咪唑-2-甲醛,再在硼氢化钠作用下,与二乙胺发生还原胺化反应制得2-二乙胺基甲基咪唑,总收率为40%。
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| 关 键 词： | 2-二乙胺基甲基咪唑 尼唑苯酮 中间体 合成 |
Synthesis of 2-(Diethylaminomethyl)imidazole |
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| WANG Dun,QUAN Zheming,WANG Shuobing,YU Fei. Synthesis of 2-(Diethylaminomethyl)imidazole[J]. , 2008, 39(10) |
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| Authors: | WANG Dun QUAN Zheming WANG Shuobing YU Fei |
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| Abstract: | Imidazole-2-carboxaldehyde,which was synthesized by four steps from imidazole and benzoyl chloride,reacted with diethylamine in the presence of sodium borohydride to give 2-(diethylaminomethyl)imidazole with an overall yield of 40%. |
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| Keywords: | 2-(diethylaminomethyl)imidazole nizofenone intermediate synthesis |
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