HR-HPV阳性宫颈癌患者宫颈组织匀浆上清液IL-17、IL-6水平及意义

目的 探讨高危型人乳头瘤病毒(HR-HPV)阳性宫颈癌患者宫颈组织匀浆上清液白细胞介素-17(IL-17)、IL-6水平及意义.方法 选取HR-HPV阳性宫颈癌患者87例,其中HR-HPV单一感染患者56例,混合感染患者31例;同时选取HR-HPV阴性宫颈癌患者69例;检测宫颈组织匀浆上清液IL-17、IL-6水平.结...

Levels and Significance of IL-17 and IL-6 in Cervical Homogenate Supernatant ofPatients with HR-HPV Positive Cervical Cancer

Objective To investigate the levels and significance of interleukin-17( IL-17) and interleukin-6( IL-6) in cervical homogenate supernatant of high-risk human papillomavirus( HR-HPV) positive cervical cancer patients. Methods 87 patients with HR-HPV positive cervical cancer were selected,including 56 patients with single infection of HR-HPV and 31 patients with mixed infection,and 69 patients with HR-HPV negative cervical cancer were selected;the levels of IL-17 and IL-6 in cervical homogenate supernatant were detected. Results The levels of IL-17 and IL-6 in cervical tissue homogenate supernatant of HR-HPV positive cervical cancer patients were( 35. 58 ± 9. 22) pg/ml and( 28. 81 ± 7. 05) pg/ml,which were significantly higher than those of HR-HPV negative cervical cancer patients( P < 0. 05);The levels of IL-17 and IL-6 in cervical tissue homogenate supernatant of patients with HR-HPV mixed infection were( 43. 67 ± 10. 02) pg/ml and( 32. 68 ± 9. 44) pg/ml,which were significantly higher than those of patients with HR-HPV single infection of cervical cancer( P < 0. 05);The levels of IL-17 and IL-6 in cervical tissue supernatant of patients with FIGO stage Ⅲ and middle-low differentiated cervical cancer were significantly higher than those of patients with stage Ⅰ-Ⅱ and high differentiated cervical cancer( P < 0. 05). Conclusion The levels of IL-17 and IL-6 in cervical homogenate supernatant of HR-HPV positive cervical cancer patients increase,which play a role in the occurrence and development of cervical cancer.