cIAP-1、NDY-1在卵巢癌中的表达及临床意义

目的 探讨细胞凋亡抑制蛋白(cIAP-1)、组蛋白去甲基化酶(NDY-1)在卵巢癌中的表达及临床意义.方法 选取上皮性卵巢癌组织标本67例,同时选取36例卵巢良性肿瘤组织和40例正常卵巢组织,采用免疫组化染色法检测cIAP-1、NDY-1表达.结果 卵巢癌组织cIAP-1、NDY-1阳性表达率分别为89.55％和86....

Expression and Clinical Significance of cIAP-1 and NDY-1 in Ovarian Cancer

Objective To investigate the expression and clinical significance of cIAP-1 and NDY-1 in ovarian cancer.Methods 67 epithelial ovarian cancer specimens were selected,and 36 cases of benign ovarian tumor and 40 normal ovarian tissues were selected,immunohistochemical staining was used to detect the expression of cIAP-1 and NDY-1. Results The positive expression rates of cIAP-1 and NDY-1 in ovarian cancer tissues were 89. 55% and 86. 57%,which were significantly higher than those in normal ovarian tissue and ovarian benign tumor tissues( P < 0. 05);The positive rates of cIAP-1 and NDY-1 in poorly middle differentiated ovarian cancer were 100. 00% and 97. 78%,which were significantly higher than those in patients with high differentiation( P < 0. 05);The positive expression rate of NDY-1 in stage Ⅲ to Ⅳ of FIGO stage was 100. 00%,which was significantly higher than that in patients with stage Ⅰ to Ⅱ( P < 0. 05);The expression of cIAP-1 and NDY-1 in ovarian cancer tissues was positively correlated( γs= 0. 724,P < 0. 05). Conclusion The high expression of cIAP-1 and NDY-1 in ovarian cancer is related to the clinicopathological characteristics of patients,and is worthy of further study.