| 丹参酮B钠盐对局灶性脑缺血/再灌注大鼠海马神经元的保护作用 |
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| 引用本文： | 蔡青,黄淑芸,谭俊珍,王静,周涛,李春深.丹参酮B钠盐对局灶性脑缺血/再灌注大鼠海马神经元的保护作用[J].辽宁中医药大学学报,2011(1):50-53. |
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| 作者姓名： | 蔡青 黄淑芸 谭俊珍 王静 周涛 李春深 |
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| 作者单位： | 天津中医药大学; |
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| 基金项目： | 天津市高等学校科技发展基金计划项目(20070301) |
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| 摘 要： | 目的:研究丹参酮B钠盐对局灶性脑缺血再灌注损伤大鼠海马神经元的保护作用。方法:应用线栓法可逆性的阻塞大鼠大脑中动脉,制备大鼠局灶性脑缺血再灌注损伤模型。复灌24h后对大鼠进行神经学评分,并测定脑梗死率和含水量。制备脑组织病理切片,观察丹参酮B钠盐对局灶性脑缺血再灌注损伤大鼠海马组织病理学影响。结果:丹参酮B钠盐能使缺血再灌注后大鼠的神经行为明显改善,显著降低脑梗死率和含水量。脑组织切片病理学检查表明丹参酮B钠盐对缺血再灌注损伤大鼠海马具有明显保护作用。结论:丹参酮B钠盐对大鼠局灶性脑缺血再灌注损伤大鼠海马神经元具有很好的保护作用。
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| 关 键 词： | 丹参酮B钠盐 局灶性脑缺血 海马 CA1 CA3 |
Protective Effect of Sodium Tanshinone B on Hippocampus Neuron of Focal Cerebral Ischemia-Reperfusion Rats |
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| CAI Qing,HUANG Shu-yun,TAN Jun-zhen,WANG Jing,ZHOU Tao,LI Chun-shen.Protective Effect of Sodium Tanshinone B on Hippocampus Neuron of Focal Cerebral Ischemia-Reperfusion Rats[J].Journal of Liaoning University of Traditional Chinese Medicine,2011(1):50-53. |
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| Authors: | CAI Qing HUANG Shu-yun TAN Jun-zhen WANG Jing ZHOU Tao LI Chun-shen |
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| Institution: | CAI Qing,HUANG Shu-yun,TAN Jun-zhen,WANG Jing,ZHOU Tao,LI Chun-shen(Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China) |
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| Abstract: | Objective:To study the protective effect of sodium tanshinone B(sodium TanB)on hippocampus neuron of focal cerebral ischemia-reperfusion rats.Methods:The traditional Zea Longa' method was improved.The rat model of focal cerebral ischemia-reperfusion was established with middle cerebral artery occlusion(MCAO)by reversibly inserting a nylon thread.Neurological scores,infarct size and water content were determined 24h after MCAO,and at the same time the pathological changes to ischemic cerebral tissues were ob... |
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| Keywords: | Sodium Tan B focal cerebral ischemia hippocampus CA1 CA3 |
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