运动性肥大心脏心肌和血浆降钙素基因相关肽含量变化

我们的前期研究发现心血管系统自身产生和分泌的调节肽参与运动性心肌肥大形成机制，但对心血管系统肽能神经纤维分泌的神经递质是否参与其机制尚不清楚。本实验采用放射免疫方法对运动性肥大心脏心肌局部降钙素基因相关肽（ｃａｌｃｉｔｏｎｉｎｇｅｎｅｒｅｌａｔｅｄｐｅｐｔｉｄｅ，ＣＧＲＰ）含量变化进行研究。结果表明，大鼠游泳运动１０周后，心系数比对照组增加３５％，心肌ＣＧＲＰ含量明显提高７０％，血浆ＣＧＲＰ含量提高４７％。这一结果提示，ＣＧＲＰ这一心血管神经调节肽在运动性心肌肥大形成中具有重要的调节作用，从已知ＣＧＲＰ作用机理推断，ＣＧＲＰ可能对运动性肥大心脏心肌收缩性的提高和肌球蛋白α重链的增加具有积极意义

Level of Calcitonin Gene Related Peptide Left in Myocardium and Plasma are Elevated in Swimming-induced Cardiac Hypertrophied Rats

Our prior studies showed cardiac active peptides by autocrine or paracrine,such as angiotensin Ⅱ,endothelin and atrial natriuretic factor,may play important roles in physiological cardiac hypertrophied remodelling.But there is very little known about the role of calcitonin gene related peptide(CGRP), a 37 amino acids neuropeptide in nerves found throughout all regions of the heart,in physiological cardiac hypertrophied remodelling.The level of CGRP in swimming induced hypertrophied myocardium and plasma were measured by radioimmunoassay.Rats were subjected to a 10 weeks swimming program.The result showed that swimmers increased their left ventricular weights by 35%(p<0.05) and level of CGRP in myocardium and plasma were increased by 70% and 47% after,compared with matched sedentary controls (p<0.05).It suggests that the chronic hypertrophied response if the heart to physiological loads is influenced by the neuropeptide in heart nerves such as CGRP.