颅高压频谱分析中M波的发现及其产生机制的初步探讨

目的:对颅高压中低频成分进行频谱分析,发现存在一种频率为0.1～0.2Hz的波动,记为M波。初步探讨M波的产生条件和变化规律,并采用药物干预研究分析其影响因素。方法:5条实验犬安置硬膜外球囊并注液制成颅高压模型。在颅内压升高过程中,采用频谱分析颅压波动;一旦发现出现M波,则分别予以副交感神经阻断剂阿托品,普萘洛尔及甘露醇干预,并观察M波变化。结果:M波多在颅压水平较高及颅压升高后阶段出现,可以被阿托品抑制。结论:M波可能是机体在颅高压状态下,由副交感神经系统反射而产生的反应,其持续存在提示预后不良。

The Finding of M Wave During the Study of Intracranial Hypertension with Frequency-Spectrum Analysis and the Corresponding Initial Probation of Its Emerging Mechanism

Aim :In the study of the low-frequency-component changes of ICP with Frequency-Spectrum analysis during intracranial hypertension, a mechanically unknown pulse wave (labelled as M wave) with its frequency at 0.1-0.2 Hz was showed continually. With several medical trials some emerging condition, variation regularity and influencing factor of M wave were analysed. Methods : Five health mongrel dogs were used to establish models of intracranial hypertension by arranging latex sacculus epidurally and injecting physiological saline. During ICP increasing process Frequency-Spectrum analysis was introduced to monitor if M wave emerged or not. If M wave emerged, then atropine, practolol and manitol were respectively intervened. Results : M wave almost emerged in the high level of intracranial hypertension and the later stage of the volume loading process, and it could be restrained by atropine. Conclusion: M wave might be the response of the body that was efferent by the parasympathetic nerve of the heart. The constant existence of M wave in ICP might be the poor prognosis.