| 养肝益水颗粒对SHR大鼠血压及ET-1、NO的影响 |
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| 引用本文： | 戴小华,郑林,杨帆,梁国庆. 养肝益水颗粒对SHR大鼠血压及ET-1、NO的影响[J]. 安徽医药, 2009, 13(2): 147-149 |
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| 作者姓名： | 戴小华 郑林 杨帆 梁国庆 |
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| 作者单位： | 安徽中医学院第一附属医院心内科,安徽,合肥,230031;浙江省象山县第一人民医院,浙江,象山,315700 |
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| 摘 要： | 目的通过对自发性高血压大鼠（SHR）血压、循环及肾脏组织内皮素（ET-1）、一氧化氮（NO）浓度的检测，观察养肝益水颗粒对SHR大鼠肾脏保护作用。方法将SHR大鼠随机分为养肝益水颗粒治疗组（以下简称养肝益水组）、卡托普利治疗组（以下简称卡托普利组）、模型对照组，每组均8只，Wistar—Kyoto（WKY）大鼠8只作为正常对照组。灌胃6周后处死，检测其血压、循环及肾脏组织内ET-1及NO的浓度。结果养肝益水颗粒能降低SHR大鼠血压进行性增高的趋势；治疗后养肝益水组循环ET-1浓度略有下降，但与模型对照组比较无明显差异（P〉0．05）；治疗后养肝益水组肾脏组织ET-1浓度较模型对照组有显著下降，其差异有统计学意义（P〈0．01）；治疗后养肝益水组循环NO浓度略有升高，但与模型对照组比较无明显差异（P〉0．05），与正常对照组比较其差异有统计学意义（P〈0．05）；治疗后养肝益水组肾脏组织NO浓度较模型对照组有显著升高，其差异有统计学意义（P〈0．01）。结论养肝益水颗粒能持久降低SHR大鼠血压，降低SHR大鼠肾脏组织ET-1浓度；升高SHR大鼠肾脏组织NO浓度，从而起到保护肾脏的作用。
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| 关 键 词： | 养肝益水颗粒 自发性高血压大鼠 早期肾损害 血压 ET-1 NO |
Effect of yangganyishui granule on blood pressure,ET-1 and NO in SHR |
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| DAI Xiao-hua,ZHENG Lin,YANG Fan,LIANG Guo-qin. Effect of yangganyishui granule on blood pressure,ET-1 and NO in SHR[J]. Anhui Medical and Pharmaceutical Journal, 2009, 13(2): 147-149 |
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| Authors: | DAI Xiao-hua ZHENG Lin YANG Fan LIANG Guo-qin |
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| Affiliation: | DAI Xiao-hua1,ZHENG Lin2,YANG Fan1,LIANG Guo-qin1(1.First Affiliated Hospital of Anhui College of Trdiditional Chinese Medicine,Hefei,Anhui Province 230031,2.Xiangshan First People's Hospital,Xiangshan,Zhejiang 315700) |
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| Abstract: | Aim To observe the protective effect of yangganyishui granule on spontaneous hypertension rats(SHR) with early renal damage by detecting the blood pressure,endothelin-1(ET-1) concentrations and nitricoxide(NO) concentrations of SHR.Methods Twenty-four SHR were randomly divided into three groups which include yangganyishui granule group,captopril group,model control group.Each group has eight rats.Besides,eight Wistar-Kyoto(WKY)rats belong to normal control group.After 6 weeks,all of the rats were put to dea... |
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| Keywords: | ET-1 NO |
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