Maternal residential pesticide use during pregnancy and risk of malignant childhood brain tumors: A pooled analysis of the ESCALE and ESTELLE studies (SFCE) |
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| Authors: | Nicolas Vidart d'Egurbide Bagazgoïtia Helen D. Bailey Laurent Orsi Brigitte Lacour Léa Guerrini‐Rousseau Anne‐Isabelle Bertozzi Pierre Leblond Cécile Faure‐Conter Isabelle Pellier Claire Freycon François Doz Stéphanie Puget Stéphane Ducassou Jacqueline Clavel |
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| Affiliation: | 1. INSERM, Université Paris‐Descartes, Université Sorbonne‐Paris‐Cité, CRESS‐EPICEA Epidémiologie des cancers de l'enfant et de l'adolescent, Paris, France;2. RNCE – National Registry of Childhood Cancers, Inserm, Villejuif and CHU de Nancy, France;3. Gustave Roussy, Département de cancérologie de l'enfant et de l'adolescent, Villejuif, France;4. Unité d'Hémato‐Immuno‐Oncologie pédiatrique, P?le Pédiatrique, CHU Toulouse, France;5. Pediatric Oncology Unit, Oscar Lambret Comprehensive Cancer Center, Lille, France;6. Institut d'hématologie et d'oncologie pédiatrique, IHOPe, Centre Léon Bérard, Lyon, France;7. Unité immuno‐hémato‐oncopédiatrie, CHU d'Angers, Angers, France;8. Clinique de pédiatrie, H?pital Couple Enfant, CHU Grenoble‐Alpes, Grenoble, France;9. Département de Pédiatrie‐Adolescents et Jeunes Adultes, Institut Curie, et Université Paris Descartes, Paris, France;10. Service de neurochirurgie pédiatrique, H?pital Necker‐Enfants malades, Université Paris Descartes, Sorbonne Paris Cité, Paris, France;11. Service d'onco‐hématologie pédiatrique, H?pital Pellegrin Tripode, Bordeaux, France |
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| Abstract: | Some previous epidemiological studies have suggested that pesticide exposure during pregnancy may have a possible role in the development of childhood brain tumors (CBT). We pooled data from two French national population‐based, case–control studies to investigate the association between maternal residential use of pesticides during pregnancy and the risk of CBT. The mothers of 437 CBT cases and 3,102 controls aged under 15 years who resided in France at diagnosis/interview, frequency‐matched by age and gender, answered a structured telephone interview conducted by trained interviewers. Unconditional logistic regression was used to estimate pooled odds ratio (OR) and 95% confidence intervals (95% CI). CBT was significantly associated with the maternal home use of pesticides during pregnancy (OR 1.4, 95% CI 1.2–1.8) and, more specifically, with insecticide (OR 1.4, 1.2–1.8). We could not draw any conclusions about herbicides and/or fungicides because few women used them during pregnancy and most of these mothers also used insecticides. Although potential recall bias cannot be excluded, our findings of this pooled analysis support the hypothesis that residential maternal use of pesticides during pregnancy and particularly insecticides may increase the risk of CBT. Future investigations to verify these findings and to explore for CBT subtypes and dose–response are necessary to have a better understanding of the possible role of pesticides in etiology of CBT. |
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| Keywords: | childhood cancer brain tumors pesticides risk factors case– control studies France |
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