| 瑞格列奈片的溶出度研究 |
| |
| 引用本文： | 马红玲,林聪,孔丽,徐平声. 瑞格列奈片的溶出度研究[J]. 中南药学, 2012, 10(11): 822-825 |
| |
| 作者姓名： | 马红玲 林聪 孔丽 徐平声 |
| |
| 作者单位： | 1. 中南大学湘雅医院药剂科,长沙 410008;中南大学药学院,长沙410013
2. 中南大学湘雅医院药剂科,长沙,410008 |
| |
| 摘 要： | 目的考察自制药瑞格列奈片在4种介质中的溶出度及溶出曲线,评价其内在质量。方法分别以水、0.1 mol L-1盐酸、pH=5.0枸橼酸-磷酸盐缓冲液和pH=6.8磷酸盐缓冲液作为溶出介质,溶出液采用高效液相色谱-荧光检测法测定,f2相似因子法用于结果判定。结果自制瑞格列奈片在4种介质中的溶出行为与参比瑞格列奈片相似。结论自制瑞格列奈片与参比瑞格列奈片相比,溶出度无显著差异。
|
| 关 键 词： | 瑞格列奈片 溶出度 相似因子 |
Dissolution of repaglinide tablets |
| |
| MA Hong-ling , LIN Cong , KONG Li , XU Ping-sheng. Dissolution of repaglinide tablets[J]. Central South Pharmacy, 2012, 10(11): 822-825 |
| |
| Authors: | MA Hong-ling LIN Cong KONG Li XU Ping-sheng |
| |
| Affiliation: | 1(1.Department of Pharmacy,Xiangya Hospital,Central South University,Changsha 410008;2.College of Pharmaceutical Sciences,Central South University,Changsha 410013) |
| |
| Abstract: | Objective To investigate the dissolution of generic repaglinide tablets in 4 media and evaluate the internal quality.Methods Water,0.1 mol ？ L-1 hydiochlorie acid solution,pH=5.0 citrate phosphate buffer solution and pH=6.8 phosphate buffer solution were selected as the 4 dissolution media.HPLC and fluorescence detection were used for the determination.f2 similar factor method was used to judge the results.Results The dissolution behavior of generic repaglinide tablets was similar to that of the reference in the 4 media.Conclusion There is no obvious diversity between generic repaglinide tablets and reference repaglinide tablets. |
| |
| Keywords: | repaglinide tablet dissolution similarity factor |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
