美蓝法乳腺癌前哨淋巴结活检的手术配合

目的:探讨美蓝法乳腺癌前哨淋巴结活检技术(Sentinellymphnodebiopsy,SLNB)的可行性及其与手术的配合。方法:本组32例T1、T2患者均先行乳腺区段切除,送快速冰冻病理活检,回报确诊为乳腺癌后于术中应用美蓝行前哨淋巴结活检,同时进行腋淋巴结清扫(Axillarylymphnodedissection,ALND)。术后对全部前哨淋巴结(SLN)和腋淋巴结(ALN)行常规病理检查。结果:32例中检出SLN者29例,检出率为90.63%(29/32),本组准确率为84.38%(27/32);灵敏度为91.67%(11/12),即预测符合率;假阴性率为16.67%(2/12);假阳性率为0。结论:应用美蓝示踪定位SLNB,能准确预测T1、T2乳腺癌患者的腋淋巴结转移状况,与手术配合易于控制活检的时间,成功率较高。

Intraoperative Sentinel Lymph Node Biopsy with Methylene Blue during Surgical Procedure of Breast Cancer

Objective: To evaluate the feasibility of intra-operative sentinel lymph node biopsy (SLNB) in patients with breast cancer. Methods: Intra-operative sentinel lymph node biopsy was performed in 32 patients with T1 and T2 breast cancer, using Methylene blue dye. All of the SLN and ALN were evaluated pathologically after the operations. Results: Of the 29 in 32 patients, SLN was successfully identified, with a detection rate of 90.63% (29/32). The accuracy of SLN biopsy in this study was 84.38% (27/32), sensitivity was 91.67% (11/12), false negative rate was 16.67% (2/12) and false positive rate was zero. Conclusion: Our study indicates that intra-operative lymphatic mapping using methylene blue and SLN can accurately predict the axillary lymph node status of the (T1,T2) cancer patients.