| PTTG、C-MYC基因过表达与非小细胞肺癌发生、发展的关系及其临床意义 |
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| 引用本文： | 任丹,;王先丽.PTTG、C-MYC基因过表达与非小细胞肺癌发生、发展的关系及其临床意义[J].华西医学,2009(11):2863-2864. |
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| 作者姓名： | 任丹 ;王先丽 |
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| 作者单位： | [1]湖北恩施自治州中心医院胸心外科,湖北恩施445000; [2]湖北民族学院医学院,湖北恩施445000 |
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| 摘 要： | 目的：探讨PTTG的表达在非小细胞肺癌发生、发展中的作用及其与C-MYC蛋白表达的关系。方法：应用免疫组化SP法检测PTTG、C-MYC二种蛋白在44例非小细胞肺癌、20例肺良性病变组织和12例正常支气管粘膜上皮组织中的表达。结果：PTTG和C-MYC蛋白在非小细胞肺癌组织中的表达明显高于肺良性病变组及癌旁组织,在TNM分期、淋巴结转移组间差别有统计学意义。非小细胞肺癌组织中PTTG与C-MYC表达呈显著正相关。结论：提示PTTG和C-MYC可能参与了非小细胞肺癌的发生和发展,可作为反映其生物学行为的指标。
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| 关 键 词： | 非小细胞肺癌 PTTG C-MYC 免疫组织化学 |
Overexpressions of PTTG and C-MYC in Non-small Cell Lung Cancer and their Clinical Significances |
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| Institution: | REN Dan WANG Xian-li2.1.Department of Cardiothoracic Surgery,The Central Hospital of Enshi Prefecture,Enshi 445000,China;2.Medical College of Hubei University for Nationalities,Enshi 445000,China |
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| Abstract: | Objective：To investigate the expression of PTTG and its relationship with expressions of C-MYC protein in human non-small cell lung cancer（NSCLC）.Methods：Immunohistochemical methods were applied to detect the expression of PTTG,C-MYCproteins in 44 surgical specimens from NSCLC patients,20 pneumonic benign lesion and 19 normal bronchial epithelium.Results：There were high erexpressions of PTTG,C-MYC in NSCLC tissues than inadjacent tissues and benign lesions.There were statistical relationships between their expressions and TNM stage,lymphnode metastasis.The expression of PTTG was positively correlated with C-MYC.Conclusion：Over-expression of PTTG, C-MYC may be related to human NSCLC,PTTG and C-MYC play a cooperative role inthe process of NSCLC,all of them may be used as important indices for biologic behavior of NSCLC. |
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| Keywords: | lung carcinoma non-small cell PTTG C-MYC immunohistochemistry |
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