肝素钠治疗过敏性紫癜性肾炎的临床疗效及安全性研究

目的：探讨肝素在预防过敏性紫癜性肾炎中的疗效及安全性。方法：采用随机对照的方法,将98例过敏性紫癜患儿分为肝素治疗组（49例）和对照组（49例）,肝素组给予肝素钠100～150 U加入5%葡萄糖100～200 mL中静脉点滴,每日1次,连用5～7天,以后每两周查尿常规1次,至少观察3个月或以上。结果：肝素治疗组发生肾炎3例（6.1%）,对照组发生肾炎11例（22.4%）,肝素治疗组肾炎发生率低于对照组（0.01〈P≤0.05）。结论：肝素对预防紫癜性肾炎的发生有效,且不良反应少。

Heparin Treatment of Allergic Purpura Nephritis the Clinical Efficacy and Safety Study

Objective：To investigate the heparin in the prevention of allergic purpura nephritis in the efficacy and safety.Methods：A randomized-controlled method,98 cases of allergic purpura patients were divided into heparin in the treatment group（49 cases） and control group（49 cases）,heparin group received heparin,100-150 u in 5%glucose 100～200 mL in the intravenous drip,day 1,used in conjunction 5-7 days,after a routine urine check every two weeks times,at least for 3 months or more.Results：The results of heparin treatment group occurred nephritis in 3 cases （6.1%）,glomerulonephritis in 11 cases in control group（22.4%）,glomerulonephritis incidence of heparin in the treatment group than the control group（0.01P≤0.05）.Conclusion：heparin in preventing the occurrence of Henoch -Schonlein purpura nephritis and effective,and less adverse reactions.