复方苦参注射液配合化疗治疗晚期胃癌30例临床观察

目的：观察复方苦参注射液配合化疗治疗晚期胃癌的临床疗效。方法：将60例晚期胃癌患者分为两组,两组均采用FOLFOX方案化疗,21天为1个周期;2个周期评价效疗。治疗组30例加用复方苦参注射液治疗,14天为1疗程,2个疗程评价疗效。观察近期疗效及临床证候变化、生存质量及毒副反应变化。结果：两组近期疗效比较,治疗组与对照组总缓解率分别为43.3%和40.0%（P〉0.05）;两组临床证候变化比较,治疗组与对照组总改善率分别为80.0%和60.0%（P〈0.05）;两组生存质量变化比较,治疗组与对照组提高稳定率分别为86.7%和56.7%（P〈0.05）;中位生存期分别为8个月和5个月;两组毒副反应比较,治疗组毒副反应明显低于对照组（P〈0.05）。结论：复方苦参注射液配合化疗治疗晚期胃癌具有一定抗肿瘤作用,能缓解疼痛症状及临床症状,减轻化疗毒副反应,提高生活质量,延长生存期。

Effect of Combination of FuFang Ku Shen Zhusheye and Chemotherapy for Treatment of 30 Advanced Gastric Cancer Patients

Objective：To study the effect of combination FuFang Ku Shen Zhusheye and chemotherapy for treatment of advanced gastric cancer.Methods：Sixty patients with advanced gastric cancer were divided into two groups, all used with FOLFOX regimen,21 days a cycle;two-cycle assessment of treatment effect.The treatment group were treated with the FuFang Ku Shen Zhusheye plus treatment,a course of treatment for 14 days,the effect were evaluated after two courses.The clinical symptoms and living quality,toxicity were dynamically observed.Results：Both short-term effect of comparison,the overall response rates of the treatment group and the control group were 43.3% and 40.0%（P0.05）;The rates of clinical symptoms of the treatment group and the control group were 80.0%and 60.0%respectively（P0.05）;the rates of increasing of living quality were respectively 86.7%and 56.7%（P0.05）;the median survival time was 8 months and 5 months;the toxicity of the treatment group was significantly lower than that of the control group（P0.05）.Conclusion：Treating advanced gastric cancer by use of FuFang Ku Shen Zhusheye combination with chemotherapy is helpful to reducing the pain symptoms,promoting the clinical symptoms, reducing the chemotherapy side effects,improving quality of life and prolonging the survival time.