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| 桑寄生对培养的人HepG2细胞葡萄糖消耗作用的影响 | |
| 引用本文： | 汪宁,朱荃,周义维,童黄锦.桑寄生对培养的人HepG2细胞葡萄糖消耗作用的影响[J].中华中医药学刊,2006,24(3):442-443. |
| 作者姓名： | 汪宁 朱荃 周义维 童黄锦 |
| 作者单位： | 1. 南京中医药大学,江苏,南京,210029;安徽中医学院药学院,安徽,合肥,230038 2. 南京中医药大学国家规范化中药药理实验室,江苏,南京,210029 3. 安徽中医学院药学院,安徽,合肥,230038 |
| 基金项目： | 安徽省高校青年教师科研项目 |
| 摘 要： | 目的:研究桑寄生对培养人HepG2细胞的葡萄糖消耗作用,初步探讨桑寄生的降糖作用机理。方法:采用人的培养的HepG2细胞,检测24h后培养液中葡萄糖的消耗量,用MTT法监测细胞增殖的情况。结果:桑寄生在高糖状态下可使HepG2细胞的葡萄糖消耗量增加,对胰岛素刺激的HepG2细胞的葡萄糖消耗量增加有协同作用。结论:促进外周组织的葡萄糖代谢、提高肝细胞对胰岛素的敏感性可能是桑寄生防治2型糖尿病的作用机理之一。 |
| 关 键 词： | HepG2细胞 桑寄生 葡萄糖消耗 |
| 文章编号： | 1009-5276(2006)03-0442-02 |
| 修稿时间： | 2005年9月13日 |
Effects of Extract of Herba Taxilli on Glucose Consumption in Cultured HepG2 Cells of Human |
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| WANG Ning,ZHU Quan,ZHOU Yi-wei,TONG Huang-jing.Effects of Extract of Herba Taxilli on Glucose Consumption in Cultured HepG2 Cells of Human[J].Chinese Archives of Traditional Chinese Medicine,2006,24(3):442-443. | |
| Authors: | WANG Ning ZHU Quan ZHOU Yi-wei TONG Huang-jing |
| Abstract: | Objective:To observe the effect of extracts of Herba taxilli on glucose consumption in cultured HepG2 cells and investigate the hypoglycemic mechanism of it initially.Methods:Cultured HepG2 cells of human were used to detect the 24(hours') consumption of glucose in Cultured fluid,MTT assay was used to monitor the proliferation of the HepG2 cells.Results:Herba taxilli could increase the glucose consumption of HepG2 cells and enhance the glucose consumption in coordination with insulin.Conclusion:Promoting the glucose consumption rate of peripheral tissue and enhance the sensitivity of hepatocytes to insulin may be one of the possible hypoglycemic mechanisms of Herba taxilli. |
| Keywords: | HepG2 cell herba taxilli glucose consumption |
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