卡维地洛治疗充血性心力衰竭的疗效观察

目的：观察卡维地洛治疗慢性充血性心力衰竭（CHF）的临床疗效。方法：将90例CHF患者随机分为卡维地洛组（治疗组）和常规治疗组（对照组）各45例。常规治疗组使用洋地黄、利尿剂、血管紧张素转换酶抑制剂、硝酸酯类等药物治疗,卡维地洛组在常规治疗的基础上,加用卡维地洛5mg/d,只要能耐受,尽可能递增到10～20mg/d,疗程24周。每周评定心功能,治疗前、后检查超声心动图,记录不良反应。结果：卡维地洛组心功能分级、左室射血分数（LVEF）明显改善（P〈0.01）,左室舒张末期内径（LVEDD）和收缩末期内径（LVESD）明显降低,与对照组比较,差异有统计学意义（P〈0.01,P〈0.05）。结论：卡维地洛治疗心力衰竭能改善心功能,改善左室重塑,安全有效。

Efficacy of carvedilol in treatment of chronic heart failure

Objective：To evaluate the efficacy and safety of carvedilol in treatment of chronic heart failure （CHF）. Meth-ods：90 patients with CHF were randomly divided into carvedilol group （45cases） and control group （45cases）. Two groups were treated with the routine medicine,including digitalis,diuretics,ACEI and niteates.Carvedilol was added to carvedilol group. Carvedilol began from 5 mg per day and was gradually increased to 10-20 mg per day if they were tolerated. The treatment was lasted for 24 weeks.The heart function was evaluated once a week,and LVEF,LVEDD and LVESD were evaluated by echocardiography before and after treatment. Symptoms and signs were recorded. Results：After treatment,the heart function and LVEF significantly increased. LVEDD,LVESD in carvedilol group were reduced significantly. There was significantly difference between the two groups. Conclusion：Carvedilol is effective and safe in treating mild and moderate chronic congestive heart failure,which can improve the remodeling of left ventricle.