Inhibitory effects of Ougi-keishi-gomotsu-to,a traditional herbal medicine,on lipid peroxidation and protein oxidative modification

Ougi-Keishi-gomotsu-to, a traditional herbal medicine, is a representative drug for patients with abnormal sensation and pain in the legs in neuropathy. It was shown to have inhibitory effects on lipid peroxidation and protein oxidative modification by copper. The effects were similar to and stronger than those of mannitol and superoxide dismutase as free radical scavengers. These results demonstrated that Ougi-keishi-gomotsu-to has inhibitory effects on oxidative stress induced by metal. Copyright© 1998 John Wiley & Sons, Ltd.