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Screening of antiinflammatory medicinal plants used in traditional medicine against skin diseases
Authors:
M J Cullar
R M Giner
M C Recio
M J Just
S Mez
S Cerd
J L Ríos
Abstract:
The antiinflammatory activity of twelve medicinal plants used against skin disorders were tested in different experimental models of topical inflammation and one
in vitro
inhibitory test against phospholipase A
2
(PLA
2
) from
Naja naja
venom.
Forsythia suspensa
was the most active species on the arachidonic acid (AA) topical test. This last species together with
Astragalus membranaceus
and
Ranunculus sceleratus
were the most active on the 12-O-tetradecanoylphorbol-13-acetate (TPA) acute ear oedema test.
Scrophularia auriculata
was the most active on multiple topical applications of TPA and on the oxazolone-induced delayed type hypersensitivity (DTH).
Santolina chamaecyparissus
was the only species that inhibited PLA
2
in vitro
. © 1998 John Wiley & Sons, Ltd.
Keywords:
medicinal plants
traditional Chinese medicine
antiinflammatory activity
12-o-tetradecanoylphorbol-13-acetate
TPA
arachidonic acid
AA
oxazolone delayed-type hypersensitivity
phospholipase A2 inhibition
PLA2
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