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Inhibition of angiotensin II receptor binding by quinolone alkaloids from Evodia rutaecarpa |
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| Authors: | Hyun Sun Lee Won Keun Oh Hee Cheol Choi Jun Won Lee Dae Ook Kang Chan Sun Park Tae-Ick Mheen Jong Seog Ahn |
| Abstract: | A biologically monitored fractionation of methanol extracts of the fruit of Evodia rutaecarpa led to the isolation of quinolone alkaloids, evocarpin (1), 1-methyl-2-(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (2) and 1-methyl-2-(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone (3) as blockers of angiotensin II receptor binding with IC50 values of 43.4 μM, 34.1 μM and 48.2 μM, respectively. © 1998 John Wiley & Sons, Ltd. |
| Keywords: | angiotensin II receptor binding quinolone alkaloid Evodia rutaecarpa Rutaceae |