人工肝联合肝移植治疗重型肝炎的初步研究

目的 观察并评价混合人工肝支持系统联合肝移植在救治重型病毒性肝炎（重型肝炎）中的作用与疗效。方法 采用自行研制的体外混合人工肝支持系统对8例中晚期重型肝炎患者进行人工肝过渡支持治疗，3－14d后行原位肝移植术。结果 8例重型肝炎患者经混合人工肝支持，肝衰竭得到有效控制，均成功等到肝移植。肝移植后4例存活，存活率为50％，另4例因肺部感染、肝肾综合征等死亡。结论 人工肝支持系统与肝移植联合可作为中晚期重型肝炎肝衰竭患者治疗的有效手段。

Treatment of severe hepatitis with artificial liver support system and liver transplantation

Objective To observe and investigate the efficacy of the hybrid artificial liver support system plus liver transplantation in the treatments of patients with severe viral hepatitis. Methods Eight severe viral hepatitis patients with metaphase and advanced stage liver failure received the artificial liver support using a self-aommand extracorporeal hybrid artificial liver support system and orthotopic liver transplantation after the artificial support for 3-14days. Results The liver failure of the 8 patients was controlled by the hybrid artificial liver support effectively. All patients were successfully bridged to orthotopic liver transplantation. Four out of the eight patients survived after transplantation. Four patients died of pulmonary infection or hepatorenal syndrome. Conclusions Artificial liver support system conbined with liver transplantation can be regarded as an efficient measure for the treatment of metaphase and advanced stage patients of severe viral hepatitis.