| 肝炎平对肝纤维化肝组织中去甲肾上腺素和多巴胺的影响 |
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| 引用本文： | 张芳杰,晏维,高啸,郭燕,但自力,赵秋,唐望先.肝炎平对肝纤维化肝组织中去甲肾上腺素和多巴胺的影响[J].中西医结合肝病杂志,2006,16(2):84-86,T0001. |
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| 作者姓名： | 张芳杰 晏维 高啸 郭燕 但自力 赵秋 唐望先 |
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| 作者单位： | 华中科技大学同济医学院同济医院肝病研究所,湖北,武汉,430030 |
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| 摘 要： | 目的：探讨肝炎平在四氯化碳（CCl4）诱导的肝纤维化模型中对肝脏中去甲肾上腺素（NE）和多巴胺（DA）的影响及其抗肝纤维化的可能机制。方法：CCl4诱导大鼠慢性肝纤维化模型。随机分为正常组、肝纤维化模型组和肝炎平治疗组。用高效液相色谱-电化学（HPLC-ECD）法检测肝组织中NE和DA水平。结果：肝炎平组和模型组大鼠肝组织内NE含量明显低于正常组（P〈0．01），且模型组NE含量低于肝炎平组（P〈0．05）；而DA在3组中的含量差异无显著性意义（P〉0．05）。结论：肝炎平可增加肝纤维化肝组织中NE的含量，可能主要通过调节肝纤维化大鼠肝脏中的NE含量而达到抗肝纤维化的作用。
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| 关 键 词： | 肝炎平/药效学 肝纤维化 去甲肾上腺素 多巴胺 高效液相色谱-电化学 大鼠 |
| 收稿时间： | 2005-10-12 |
| 修稿时间： | 2005-10-12 |
The effect of Ganyanping on Norepinephrine and Dopamine in liver tissue of fibrosis |
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| ZHANG Fang-jie, GAO Xiao, YAN Wei,et al..The effect of Ganyanping on Norepinephrine and Dopamine in liver tissue of fibrosis[J].Chinese Journal of Integrated Traditonal and Western Medicine on Liver Diseases,2006,16(2):84-86,T0001. |
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| Authors: | ZHANG Fang-jie GAO Xiao YAN Wei |
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| Institution: | Institute of Liver Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Tehnology Wuhan Hubei, 430030 China |
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| Abstract: | Objective:To investigate the effect fo Ganyanping (GYP) on Norepinephrine(NE) and Dopamine(DA) and the possible mechanism resisting hepatic fibrosis induced by carbon tetrachloride(CCl_4).Methods:The 40 rats were randomly diveded into control group,model group and GYP-treated group.The NE and DA concentrations in liver tissue were determined with high performanec liquid chromatography-electrochemical detector(HPLC-ECD).Results:The levels of NE in model and GYP-treated group were obviously less than in control group(P<0.01),and NE in model group was less than in GYP-treated group(P<0.05);while DA was similar in the three groups(P>0.05).Conclusion:GYP could increase the NE concentrations in liver tissue of fibrosis,and achieved to inhibit the hepatic fibrosis mainly by regulating the levels of NE in rats with hepatic fibrosis. |
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| Keywords: | Ganyanping/pharmacodynarnics hepatic fibrosis norepinephrine dopamine high performance liquid chromatography-electrochemical detecter rat |
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